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Assignment of the gene encoding cytosolic phosphoenolpyruvate carboxykinase (GTP) toMus musculus chromosome 2

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Somatic Cell and Molecular Genetics

Abstract

The structural gene Pck-1, encoding cytosolic phosphoenolpyruvate carboxykinase (GTP) (PEPCK; EC 4.1.1.32), has been assigned to mouse chromosome 2. This assignment was made based on genomic Southern transfer of rat-mouse and hamster-mouse hybrid DNAs using a rat kidney cloned cDNA of the PEPCK gene as a probe. Conclusive evidence for the cosegregation of the PEPCK gene with mouse chromosome 2 was obtained using a monochromosomal microcell hybrid that selectively retained a Robertsonian translocation between mouse autosomes 2 and 8 and its back-selected hybrid clone.

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Authors and Affiliations

  1. Department of Microbiology and the Comprehensive Cancer Center, University of Southern California School of Medicine, 90033, Los Angeles, California

    Janis Lem & R. E. K. Fournier

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  1. Janis Lem
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  2. R. E. K. Fournier
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Lem, J., Fournier, R.E.K. Assignment of the gene encoding cytosolic phosphoenolpyruvate carboxykinase (GTP) toMus musculus chromosome 2. Somat Cell Mol Genet 11, 633–638 (1985). https://doi.org/10.1007/BF01534728

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  • DOI: https://doi.org/10.1007/BF01534728

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