Abstract
Concordant segregation of the expression of the α subunit of human hexosaminidase A, human mannosephosphate isomerase, and pyruvate kinase was observed in somatic cell hybrids between either thymidine kinase-deficient mouse cells or thymidine kinase-deficient Chinese hamster cells and human white blood cells carrying a translocation of the distal half (q22-qter) of the long arm of chromosome 15 to chromosome 17. A positive correlation was established between the expression of these human phenotypes and the presence of the distal half of the long arm of human chromosome 15.
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Chern, C.J., Kennett, R., Engel, E. et al. Assignment of the structural genes for the α subunit of hexosaminidase A, mannosephosphate isomerase, and pyruvate kinase to the region q22-qter of human chromosome 15. Somat Cell Mol Genet 3, 553–560 (1977). https://doi.org/10.1007/BF01539065
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DOI: https://doi.org/10.1007/BF01539065