Abstract
Associations of the VNTR-17 and 5-HTTLPR polymorphisms of the serotonin transporter gene with affective disorders, including depression, have been found. These polymorphisms were analyzed in two groups of Russian probands: patients with endogenous psychoses and control individuals without mental disorders (423 and 277 persons, respectively). No associations were found between VNTR-17 genotypes or alleles and the diseases. However, the frequency of10/10 (VNTR-17) homozygotes increased with age in both patients and healthy persons. The results of the analysis of the 5-HTTLPR polymorphism suggest an association of the short (s) allele of the 5-HTTLPR polymorphism with schizophrenia and schizoaffective psychoses, but not with affective disorders.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Lesch, K., Molecular Biology, Pharmacology, and Genetics of the Serotonin Transporter: Psychobiological and Clinical Implications, Serotoninergic Neurons and 5-HT Receptors in the CNS, Baumgarten, H. and Gothert, M., Eds., New York: Springer-Verlag, 1997, pp. 671–705.
Blakely, R., De Felice, L., and Hartzell, H., Molecular Physiology of Norepinephrine and Serotonin Transporters, J. Exp. Biol., 1994, vol. 196, pp. 263–282.
Lesch, K. and Mossner, R., 5-HTT Transporter and Neuroplasticity, Biol. Psychiatry, 1998, vol. 44, pp. 179–192.
Lesch, K., Balling, U., Gross, J., et al., Organization of the Human Serotonin Transporter Gene, J. Neural Transm.: Gen. Sect., 1994, vol. 95, pp. 157–164.
Altemus, M., Murphy, D., Greenberg, B., and Lesch, K., Am. J. Med. Genet., 1996, vol. 67, pp. 104–109.
De Bella, D., Catalano, M., and Bolling, U., Systematic Screening for Mutations in the Coding Region of the 5-HTT Gene Using PCR and DGGE, Am. J. Med. Genet., 1996, vol. 67, pp. 541–545.
Lesch, K., Franzek, E., Gross, J., et al., Primary Structure of the Serotonin Transporter in Unipolar Depression and Bipolar Disorder, Biol. Psychiatry, 1995, vol. 37, pp. 215–223.
Ogilvie, A., Battersby, B., Bubb, V., et al., Polymorphism in Serotonin Transporter Gene Associated with Susceptibility to Major Depression, Lancet, 1996, vol. 347, pp. 731–733.
Rees, M., Norton, N., Jones, I., et al., Association Studies of Bipolar Disorders at the Human Serotonin Transporter Gene (HSERT. 5-HTT), Mol. Psychiatry, 1997, vol. 2, pp. 398–402.
Heilis, A., Teufel, A., Petru, S., et al., Functional Promoter and Polyadenylation Site Mapping of the Human Serotonin (5-HT) Transporter Gene, J. Neural Transm.: Gen. Sect., 1995, vol. 102, pp. 247–254.
Lesch, K., Bengel, D., Heilis, A., et al., Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region, Science, 1996, vol. 274, pp. 1527–1531.
Hernandez, I. and Sokolov, B., Abnormal Expression of Serotonin Transporter mRNA in the Frontal and Temporal Cortex of Schizophrenics, Mol. Psychiatry, 1997, vol. 2, pp. 57–64.
Collier, D., Arranz, M., Sham, et al., The Serotonin Transporter Is a Potential Susceptibility Factor for Bipolar Affective Disorder, Neuroreport, 1996, vol. 3, pp. 1675–1679.
Oliveira, J., Otto, P., Vallada, H., et al., Analysis of Novel Functional Polymorphism within the Promoter Region of the Serotonin Transporter Gene (5-HTT) in Brazilian Patients Affected by Bipolar Disorder and Schizophrenia, Am. J. Med. Genet., 1998, vol. 81, no. 3, p. 225–227.
World Health Organization International Classification of Disease: ICD-10 Draft at 10th Ed., Geneva, 1989.
Cuella, D., Catalano, M., Balling, U., et al., Systematic Screening for Mutations in the Coding Region of the 5-HTT Gene Using PCR and DGGE, Am. J. Med. Genet., 1996, vol. 67, pp. 541–545.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shcherbatykh, T.V., Golimbet, V.E., Orlova, V.A. et al. Polymorphism in the Human Serotonin Transporter Gene in Endogenous Psychoses. Russian Journal of Genetics 36, 1445–1448 (2000). https://doi.org/10.1023/A:1009031626668
Issue Date:
DOI: https://doi.org/10.1023/A:1009031626668