Zusammenfassung
30jähriger Mann mit rezidivierender Hämoptoe. Die Lungenblutungen waren von Fieber und röntgenologisch flüchtigen Lungeninfiltraten in Mittel- und Untergeschossen, gleichzeitigem Abfall des Hämoglobins begleitet. Bisherige Krankheitsdauer 16 Monate, die letzten 5 Monate war der Patient völlig beschwerdefrei. Die Nierenbiopsie ergab eine momentan inaktive proliferative Herdglomerulitis, die auch elektronenmikroskopisch nachgewiesen werden konnte. Allerdings fanden sich ultrastrukturell noch deutliche Zeichen für Aktivität der Zellelemente. Die lichtmikroskopisch nur angedeutete Eisenablagerung im Deckepithel der Glomerula konnte elektronenmikroskopisch bestätigt werden. — Das Gesamtbild entspricht einem typischen Goodpasture-Syndrom.
Summary
30 year old male patient with recurrent hemoptoe. The hemorrhages of the lung were accompanied by fever and roentgenologically slight infiltrations of the middle and lower compartments of the lung with simultaneous decrease of hemoglobine. The disease having lasted 16 months the patient has been free of complaints for the last 5 months. The biopsy of the kidney resulted in the diagnosis of a momentarily inactive proliferative focal glomerulitis. This could be confirmed by electron microscopical investigation, although there were found traces of activity. of the cell elements. Deposits of iron faintly indicated under the light microscope, were confirmed by electron microscopy. The total picture corresponds to a typical Goodpasture' syndrome.
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Rohr, H.P., Zollinger, H.U., Müller, P. et al. Bioptische licht- und elektronenmikroskopische Untersuchung eines Falles von idiopathischer Lungenblutung mit Herdglomerulitis (Goodpasture-Syndrom). Klin Wochenschr 44, 952–957 (1966). https://doi.org/10.1007/BF01711467
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DOI: https://doi.org/10.1007/BF01711467