Zusammenfassung
1. Die Phenylalanin-Toleranz wurde vergleichend bei Frühgeborenen, reifen Neugeborenen, Säuglingen und Erwachsenen bestimmt. Die Untersuchung erfolgte nach intravenöser Injektion von L-Phenylalanin. Die Elimination von Phenylalanin aus dem Blut erfolgte entsprechend einer Exponentialfunktion. Zur Beurteilung des Toleranzgrades wurde die Eliminationshalbwertszeit gewählt.
2. Die Phenylalanin-Toleranz war bei den meisten Frühgeborenen herabgesetzt. Bei reifen Neugeborenen kamen Toleranzverminderungen vor; sie waren jedoch wesentlich seltener. Die meisten Neugeborenen und alle Säuglinge zeigten eine Phenylalanin-Toleranz, die der beim normalen Erwachsenen entspricht.
3. Es werden die Beziehungen diskutiert, die zwischen der Phenylalanin-Toleranz und der Aktivität der Phenylalaninhydroxylase bestehen, und es wird auf die bei neonatalen Tieren beobachteten Aktivitätsverminderung des Phenylalaninhydroxylase-Systems hingewiesen.
Summary
1. The phenylalanine tolerance was estimated after intravenous injection of L-phenylalanine in premature newborns, mature newborns, infants and normal adults. The elimination of phenylalanine from the blood followed the pattern of a monomolecular reaction. The rate of elimination was, therefore, chosen for the comparison of the degree of tolerance.
2. The tolerance of phenylalanine was markedly reduced in most of the prematures; the same was found in some of the mature newborn infants. Compared with the tolerance in adults there was no decrease of phenylalanine tolerance in most of the mature newborns and in all infants.
3. The relation of phenylalanine tolerance to the activity of phenylalanine hydroxylase and to the development of the phenylalanine hydroxylase system was discussed.
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Bremer, H.J., Neumann, W. Phenylalanin-Toleranz bei Frühgeborenen, reifen Neugeborenen, Säuglingen und Erwachsenen. Klin Wochenschr 44, 1076–1081 (1966). https://doi.org/10.1007/BF01716309
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DOI: https://doi.org/10.1007/BF01716309