Zusammenfassung
Die biologische Halbwertszeit von Aldosteron, die normalerweise 30–40 min beträgt, war bei drei nephrektomierten Patienten auf 15, 19 und 20 min verkürzt.
Summary
The biological half-time of labeled aldosterone of 30 to 40 minutes in normal man was 15, 19 and 20 minutes in three nephrectomized patients.
This is a preview of subscription content, log in via an institution to check access.
Literatur
Peterson, R. E.: Aldosterone metabolism. Recent Progr. Hormone Res.15, 231 (1959).
Coppage, W. S., D. Island, A. E. Cooner, andG. W. Liddle: Metabolism of aldosterone in normal subjects and patients with cirrhosis. Clin. Res.9, 177 (1961).
Tait, J. F., S. A. S. Tait, B. Little, andK. R. Laumas: The disappearance of 1,2-3H-aldosterone in the plasma of normal subjects. J. clin. Invest.40, 72 (1961).
Luetscher, J. A., A. J. Dowdy, A. M. Callaghan, andA. P. Cohn: Studies of secretion and metabolism of aldosterone and cortisol. Trans. Ass. Amer. Phycns75, 293 (1962).
Coppage, W. S., D. P. Island, A. E. Cooner, andG. W. Liddle: The metabolism of aldosterone in normal subjects and in patients with cirrhosis. J. clin. Invest.41, 1672 (1962).
Wolff, H. P., D. Lommer u.M. Torbica: Untersuchungen über das Plasmaaldosteron und den Aldosteronstoffwechsel bei Gesunden, Herz-, Leber- und Nierenkranken. Schweiz. med. Wschr.95, 387 (1965).
Tait, J. F., B. Little, S. A. Tait, andC. Flood: The metabolic clearance rate of aldosterone in pregnant and nonpregnant subjects estimated by both single injection and constant infusion methods. J. clin. Invest.41, 2093 (1962).
Bougas, J., C. Flood, B. Little, J. F. Tait, S. A. S. Tait, andR. Underwood: Dynamic aspects of aldosterone metabolism, p. 25. Oxford: Blackwell Sci. Publ. 1964.
Camargo C. A., A. J. Dowdy, E. W. Hancock, andJ. A. Luetscher: Decreased plasma clearance and hepatic extraction of aldosterone in patients with heart failure. J. clin. Invest.44 356 (1965).
Davis, J. O., M. J. Olichney, T. C. Brown, andP. F. Binnion: Metabolism of aldosterone in several experimental situations with altered aldosterone secretion. J. clin. Invest.44, 1433 (1965).
Bledsoe, T., G. W. Liddle, A. Riondel, D. P. Island, D. Bloomfield, andB. Sinclair-Smith: Comparative fates of intravenously and orally administered aldosterone: Evidence for extrahepatic formation of acid-hydrolysable conjugate in man. J. clin. Invest.45, 264 (1966).
Flood, C., G. Pincus, J. F. Tait, S. A. S. Tait, andS. Willoughby: The metabolism and secretion of aldosterone in elderly subjects. J. clin. Invest.46, 690 (1967).
Luetscher, J. A., E. W. Hancock, C. A. Carmago, A. J. Dowdy, andG. W. Nokes: Conjugation of 1,2-3H-aldosterone in human liver and kidneys and renal extraction of aldosterone and labeled conjugates from blood plasma. J. clin. Endocr.25, 628 (1965).
Deck, K., andW. Siegenthaler: Further experimental evidence for the formation of the acid hydrolysable conjugate of aldosterone by the kidney. Acta endocr. (Kbh.)51, 637 (1967).
Deck, K., andW. Siegenthaler: Transport of aldosterone and of the acid labile conjugate of aldosterone by tubular cells of the kidney. Acta endocr. (Kbh.)51, 648 (1967).
Möhring, J., B. Möhring, P. Endres u.W. Siegenthaler: Zur Bildung von 18-Aldosteronglucuronid in den Nieren des Hundes. Z. ges. exp. Med. (im Druck) (1967).
Möhring, J., B. Möhring u.W. Siegenthaler: Zur Bildung von 18-Aldosteronglucuronid in den Nieren des Menschen. Z. ges. exp. Med. (im Druck) (1967).
Chart, J. J., E. S. Gordon, P. Helmer, andM. Lesher: Metabolism of salt-retaining hormone by surviving liver slices. J. clin. Invest.39, 320 (1956).
Yates, F. E., J. Urquhart, andA. L. Herbst: Impairment of the enzymatic inactivation of adrenal cortical hormone following passive venous congestion of the liver. Endocr. Soc. Abstr.42, 17 (1960).
Ayres, C. R., J. O. Davis, F. Liebermann, C. C. J. Carpenter, andM. Bergmann: The effect of chronic hepatic venous congestion on the metabolism of d,1-aldosterone and d-aldosterone. J. clin. Invest.41, 884 (1962).
Tomkins, G.: Enzymatic mechanism of hormone metabolism. I. Oxidation-reduction of the steroid nucleus. Recent Progr. Hormone Res.12, 125 (1956).
Luetscher, J. A., A. P. Cohn, C. A. Camargo, A. J. Dowdy, andA. M. Callaghan: Aldosterone secretion and metabolism in hyperthyroidism and myxödema. J. clin. Endocr.23, 873 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Möhring, J., Siegenthaler, W. & Weidmann, P. Verkürzte biologische Halbwertszeit von 1,2-3H-Aldosteron bei drei nephrektomierten Patienten. Klin Wochenschr 46, 47–49 (1968). https://doi.org/10.1007/BF01725303
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01725303