Zusammenfassung
Glucoseinjektionen (0,33 g/kg Körpergewicht in 15 sec) und Arginin-Infusionen (0,5 g/kg Körpergewicht in 30 min) bei Neugeborenen verschiedenen Alters (1–2, 4 und 7 Tage) führten zum Anstieg des STH im Blut und zur Abnahme der freien Fettsäuren und des Glycerins. Die stärkste STH-Reaktion wurde bei den jüngsten Neugeborenen (1–2 Tage alt) beobachtet.
Summary
Glucose tolerance tests and arginine infusions were performed in 60 fullterm newborn infants at 1, 4, and 7 days of age. Glucose and arginine infusions were followed by an initial decrease of GH1 which was followed by an increase of GH levels exceeding base line values. Two hours after infusions GH levels were lower than in the beginning. The most pronounced changes of GH concentrations were observed in the youngest age group. FFA2 and glycerol levels initially decreased after glucose and arginine infusion.
It is suggested that GH plays an important role in protein synthesis and lipolysis particularly during the first days of life.
Literatur
Bowie, M. D., Mulligan, P. B., Schwartz, R.: Intravenous glucose tolerance in the normal newborn. The effects of a double dose of glucose and insulin. Pediatrics31, 590 (1963).
Cornblath, M., Parker, M. L., Reisner, S. H., Forbes, A. E., Daughadey, H. W.: Secretion and Metabolism of growth hormone in premature and full-term infants. J. clin. Endocr.25, 209–218 (1965).
Dost, F. H., Gladtke, E., Hattingberg, H. W., Rind, H.: Biokinetische Normwerte bei der intravenösen Glucosebelastung. Klin. Wschr.46, 503–505 (1968).
Eggstein, M., Kreutz, F. H.: Eine neue Bestimmung der Neutralfette im Blutserum und Gewebe. 1. Mitt. Prinzip, Durchführung und Besprechung der Methode. Klin. Wschr.44, 262–267 (1966).
Epstein, S., Sanu, C. E., Raben, M. S.: The effect of growth hormone and cortisone on thymidine kinase activity in rat adipose tissue. Biochim. biophys. Acta (Amst.)186, 280–285 (1969).
Euler, M. von, Larsson, Y., Persson, B.: Glucose tolerance in the neonatal period and during the first six month of life. Arch. Dis. Childh.39, 393–396 (1964).
Greenwood, F. C., Hunter, W. M., Glover, J. S.: The preparation of131J-labelled human growth hormone of high specific radioactivity. Biochem. J.89, 114 (1963).
Huggett, A. S. G., Nixon, D. A.: Enzymic determination of blood glucose. Biochem. J.66, 12 P (1957).
Laron, Z., Mannheimer, S., Nitzan, M., Goldmann, J.: Growth hormone, glucose and free fatty acid levels in mother and infant in normal, diabetic and toxaemic pregnancies. Arch. Dis. Childh.42, 24–28 (1967).
Levine, R., Luft, R.: The relation between the growth and diabetogenic effects of the so-called growth hormone of the anterior pituitary. Diabetes13, 651–655 (1964).
Merimee, T. J., Lillierap, D. A., Rabinowitz, D.: Effect of arginine on serum-levels of human growth hormone. Lancet1965 II, 668–670.
—— Rabinowitz, D., Fineberg, S. E.: Arginine-initiated release of human growth hormone. New Engl. J. Med.280, 1434–1438 (1969).
Milner, R. D. A., Wright, A. D.: Blood glucose, plasma insulin and growth hormone response to hyperglycaemia in the newborn. Clin. Sci.31, 309–315 (1966).
Novák, M.: Colorimetric ultramicromethod for the determination of free fatty acids. J. Lipid. Res.6, 431–433 (1965).
Roos, P., Fevold, H. R., Gemzell, C. A.: Preparation of human growth hormone by gel filtration. Biochem. biophys. Acta (Amst.)74, 525 (1963).
Schreier, K., Porath, U.: Eiweißsynthese in der Prä- und Postnatalperiode. In: Fortschritte der Pädologie (edit. F. Linneweh), Bd. 1. Berlin-Heidelberg-New York: Springer 1965.
Stubbe, P., Šabata, V.: Veränderungen des Wachstumshormons bei verschiedenen Gruppen von Neugeborenen. Symposion über neonatale Biochemie, Deidesheim. 24.–26. 10. 1968. Stuttgart: Hippokrates 1970.
Westphal, O.: Human growth hormone. A methodological and clinical study. Acta paediat. scand., Suppl.182 (1968).
Wolf, H., Kochsiek-Schuster, M., Löhr, H.: Enzymatische Triglyceridbestimmungen bei Kindern. Z. klin. Chem.5, 205–209 (1967).
Wool, M. S., Selenkow, H. A.: Charcoal-Dextran radioimmuno assay of human growth hormone. Acta endocr. (Kbh.)57, 109–114 (1968).
Author information
Authors and Affiliations
Additional information
Mit Unterstützung der Deutschen Forschungsgemeinschaft Stu 61/1 und Wo 69/7.
Rights and permissions
About this article
Cite this article
Stubbe, P., Wolf, H., Stolte, G. et al. Glucosebelastungen und Arginin-Infusionen bei Neugeborenen. Einfluß auf Wachstumshormon, Blutzucker, Fettsäuren und Glycerin. Klin Wochenschr 48, 918–923 (1970). https://doi.org/10.1007/BF01487631
Issue Date:
DOI: https://doi.org/10.1007/BF01487631