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Einfluß von Spironolacton auf das Regenerationsvermögen der Leber bei Ratten

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Zusammenfassung

Spironolacton verursacht sowohl bei intakten, als auch bei partiell hepatektomierten Ratten eine signifikante Gewichtszunahme der Leber, sowie eine bedeutsame Erhöhung der mitotischen Aktivität der Hepatocyten. Es wird angenommen, daß dieses nicht-toxische Arzneimittel durch Enzyminduktion in der Leber solche Vorgänge (erhöhte Proteinsynthese, Aktivierung der NADPH-bildenden Systeme) in Gang setzt, welche die Leberregeneration begünstigen.

Summary

In intact as well as in partially hepatectomized rats, spironolactone causes a significant weight increase of the liver, and a considerable rise in the mitotic activity of hepatocytes. It is assumed that this non-toxic substance activates through enzyme induction, certain mechanisms (e. g., increased protein synthesis, activation of NADPH-producing systems) which promote regeneration of the liver.

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Authors and Affiliations

  1. Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Kanada

    Eva Horvath, A. Somogyi & K. Kovacs

Authors
  1. Eva Horvath
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  2. A. Somogyi
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  3. K. Kovacs
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Horvath, E., Somogyi, A. & Kovacs, K. Einfluß von Spironolacton auf das Regenerationsvermögen der Leber bei Ratten. Klin Wochenschr 48, 385–387 (1970). https://doi.org/10.1007/BF01484876

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  • DOI: https://doi.org/10.1007/BF01484876

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