Summary
Circulating lymphocytes consist of a heterogenous cell population. Employing immunological and autoradiographic methods lymphocytes with Ig (kappa) determinants, those with membrane receptors for immune-complement complexes, lymphocytes containing Ig intracellularly and those in DNA synthesis were evaluated in normals and in patients with chronic lymphocytic leukaemia (CLL). The concept of functionally defective lymphocytes in CLL was further substantiated. The use of immunological markers for identifying thymus (T)- and bone marrow (B) derived human lymphocytes is discussed.
Zusammenfassung
Zirkulierende Lymphocyten setzen sich aus funktionell heterogenen Zellen zusammen, welche mit morphologischen Methoden allein nur ungenügend differenziert werden können. Unter Verwendung immunologischer und autoradiographischer Methoden wurden Lymphocyten mit Determinanten leichter (kappa) Ketten, Lymphocyten mit Membranreceptoren für Immun-Komplement-Komplexe, lymphatische Zellen mit cytoplasmatischem Immunglobulingehalt und Lymphocyten in DNS-Synthese bestimmt.
Gegenüber Normalpersonen waren bei Patienten mit chronischer Lymphadenose Abweichungen an mehreren dieser Lymphocytenpopulationen nachweisbar. Die Ergebnisse werden im Hinblick auf das Konzept thymus- und knochenmarkabhängiger Lymphocyten diskutiert, deren Differenzierung mit immunologischen Methoden erleichtert wird.
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Huber, H., Michlmayr, G., Asamer, H. et al. Die Differenzierung menschlicher Blutlymphocyten mit immunologischen und autoradiographischen Methoden. Klin Wochenschr 50, 504–509 (1972). https://doi.org/10.1007/BF01487294
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DOI: https://doi.org/10.1007/BF01487294