Skip to main content
SpringerLink
Log in

Aldosteron, Cortisol und Plasma-Renin-Aktivität beim Phäochromocytom

Aldosterone, eochrocortisol and plasma renin activity in phmocytoma

  • Originalien
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

Seven of eight patients with pheochromocytoma showed elevated plasma renin activity (>3 ng/ml/3 hr). Four of these seven patients simultaneously had abnormally high plasma aldosterone (>120 pg/ml). It was found by selective determinations of plasma renin activity in both renal veins that two different mechanisms may be responsible for the observed hyperreninism. Firstly, the pheochromocytoma can lead mechanically to a reduction in renal blood flow inducing an increased renin secretion. Secondly, catecholamines are known to stimulate renin secretion. Two of the eight patients with pheochromocytoma showed an increased cortisol secretion.

Zusammenfassung

Sieben von 8 Patienten mit einem Phäochromocytom zeigten eine über die Norm erhöhte Plasma-Renin-Aktivität (>3 ng/ml/3 h). Bei 4 der 7 Patienten mit Hyperreninismus konnte gleichzeitig auch ein abnorm hohes Plasma-Aldosteron nachgewiesen werden (>120 pg/ml). Seitengetrennte Bestimmungen der Plasma-Renin-Aktivität im Nierenvenenblut zweier Patienten zeigten, daß als Ursachen des Hyperreninismus sowohl eine Verringerung der Nierendurchblutung durch Tumorkompression im Sinne eines Goldblattmechanismus als auch eine Stimulation der renalen Reninsekretion durch Katecholamine in Frage kommen können. Bei 2 unserer Patienten mit einem Phäochromocytom fand sich eine über die Norm gesteigerte Cortisolsekretion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Beckerhoff, R., Uhlschmid, G., Vetter, W., Armbruster, H., Siegenthaler, W.: Plasma renin and aldosterone after renal transplantation. Kidney International,5, 39 (1974)

    PubMed  Google Scholar 

  2. Bunag, R. D., Page, I. H., McCubbin, J. M.: Neural stimulation of release of renin. Circulat. Res.19, 851 (1966)

    PubMed  Google Scholar 

  3. Bourgoignie, J., Dupont, J.-Cl., Noiret, R.: Association d'un phéochromo-cytome et d'un hypercorticism du type Cushing avec hyperaldostéron-urie. Ann. Endocr.25, 269 (1964)

    PubMed  Google Scholar 

  4. Brown, J. J., Davies, D. L., Lever, A. F., Robertson, J. I. S.: Plasma renin concentration in human hypertension. II. Renin in relation to aetiology. Brit. med. J.1965 II, 1215

    Google Scholar 

  5. Cope, O., Labbe, J. P., Raker, S. W., Bland, E. F.: Phaechromocytoma and adrenal adenoma. Report of a case with both tumors and discussion of their relation. J. clin. Endocr.12, 875 (1952)

    PubMed  Google Scholar 

  6. Endres, P., Siegenthaler, W., Baumann, K., Gysling, E., Rubli, H., Schönbeck, M., Weidmann, P., Werning, C.: Die Plasma-Renin-Aktivität im peripheren venösen Blut unter verschiedenen Stimulationsbedingungen. Dtsch. med. Wschr.94, 1049 (1969)

    PubMed  Google Scholar 

  7. Haber, E., Koerner, T., Page, L. B., Kliman, B., Purnode, A.: Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J. clin. Endocr.29, 1349 (1969)

    PubMed  Google Scholar 

  8. Katz, F. H., Romfh, P., Smith, J. A.: Episodic secretion of aldosterone in supine man: Relationship to cortisol. J. clin. Endocr.35, 178 (1972)

    PubMed  Google Scholar 

  9. Liddle, G. W., Island, D. P., Ney, R. L., Nicholson, W. E., Shimizu, N.: Non-pituitary neoplasms and Cushing's syndrome. Ectopic adrenocorticotrophic production by non-pituitary neoplasms as a cause of Cushing's syndrome. Arch. intern. Med.111, 471 (1963)

    PubMed  Google Scholar 

  10. Mathison, D., Waterhouse, C. A.: Cushing's syndrome with hypertensive crisis and mixed adrenal cortical adenoma phaechromocytoma (cortico-medullary adenoma). Amer. J. Med.47, 635 (1969)

    PubMed  Google Scholar 

  11. Mulrow, P. J., Cohn, G. L., Yesner, R.: Isolation of cortisol from a pheochromocytoma. Yale J. Biol. Med.31, 363 (1959)

    PubMed  Google Scholar 

  12. Murphy, B. E. P., Engelberg, W., Pattee, C. J.: Simple method for the determination of plasma corticoids. J. clin. Endocr.23, 293 (1963)

    PubMed  Google Scholar 

  13. Ramsey, I. D., Langlands, J. H. M.: Phaeochromocytoma with hypotension and polycythaemia. Lancet1962 II, 126

    Google Scholar 

  14. Ross, E. J., Prichard, B. N. C., Kaufman, L., Robertson, A. I. G., Harries, B. J.: Pre-operative and operative management of patients with phaeochromocytoma. Brit. med. J.1967 I, 191

    Google Scholar 

  15. Scornik, O. A., Paladini, A. C.: Significance of blood angiotensin levels in different experimental conditions. Canad. med. Ass. J.90, 269 (1964)

    PubMed  Google Scholar 

  16. Skinner, S. L., McCubbin, J. M., Page, I. H.: Control of renin secretion. Circulat. Res.15, 64 (1964)

    Google Scholar 

  17. Vander, A. J.: Effect of catecholamines and the renal nerves on renin secretion in anesthetized dog. Amer. J. Physiol.209, 659 (1965)

    PubMed  Google Scholar 

  18. Vetter, H., Berger, M., Armbruster, H., Siegenthaler, W., Werning, C., Vetter, W.: Episodic secretion of aldosterone in primary aldosteronism. Relationship to cortisol. Clin. Endocr.3, 41 (1974)

    Google Scholar 

  19. Vetter, H., Vetter, W.: High titre antiserum specific to aldosterone. Steroid. Biochem., im Druck

  20. Vetter, W., Vetter, H., Siegenthaler, W.: Radioimmunoassay for aldosterone without chromatography. 1. Determination of urinary 18-glucuronid excretion. Acta endocr. (Kbh.)74, 548 (1973)

    PubMed  Google Scholar 

  21. Vetter, W., Vetter, H., Siegenthaler, W.: Radioimmunoassay for aldosterone without chromatography. 2. Determination of plasma aldosterone. Acta endocr. (Kbh.)74, 558 (1973)

    PubMed  Google Scholar 

  22. Vetter, W., Záruba, K., Armbruster, H., Strebel, U., Beckerhoff, R., Siegenthaler, W.: Plasma aldosterone during hemodialysis in patients with terminal renal failure. Proc. Europ. Dialysis Transplant. Ass.10, 332 (1973)

    Google Scholar 

  23. Veyrat, R., Muller, A. F., Mach, R. S.: Les hyperaldostéronismes secondaires. Schweiz. med. Wschr.98, 1499 (1968)

    PubMed  Google Scholar 

  24. Wathen, R. L., Kingsbury, W. S., Stouder, D. A., Schneider, E. G., Rostorfer, H. H.: Effects of infusion of catecholamines and angiotensin II on renin release in anethetized dogs. Amer. J. Physiol.209, 1012 (1965)

    PubMed  Google Scholar 

  25. Weidmann, P., Siegenthaler, W.: Das Renin-Angiotensin-Aldosteron-System bei hypertensiven Zuständen. Dtsch. med. Wschr.92, 1953 (1967)

    PubMed  Google Scholar 

  26. Weidmann, P., Siegenthaler, W., Ziegler, W. H., Sulser, H., Endres, P., Werning, C.: Hypertension associated with tumours adjacent to renal arteries. Amer. J. Med.47, 528 (1969)

    PubMed  Google Scholar 

  27. Werning, C., Ziegler, W. H., Baumann, K., Endres, P., Gysling, E., Weidmann, P., Siegenthaler, W.: Die Plasma-Renin-Aktivität beim Phäochromocytom. Dtsch. med. Wschr.95, 117 (1970)

    PubMed  Google Scholar 

  28. Walters, G., Wyatt, G. B., Kelleher, J.: Carcinoma of the adrenal cortex presenting as a pheochromoeytoma: Report of a case. J. clin. Endocr.22, 575 (1962)

    PubMed  Google Scholar 

  29. Williams, G. A., Crockett, Ch. L., Butler, W. W. S., Crispell, K. R.: The coexistence of pheochromocytoma and adrenocortical hyperplasia. J. clin. Endocr.20, 622 (1960)

    PubMed  Google Scholar 

  30. Wilson, R. J., Craig, G. M., Mills, I. H.: Metabolic studies in a patient with a phaeochromocytoma associated with hypokalaemia and hyperaldosteronism. J. Endocr.56, 69 (1973)

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medizinische Universitäts-Poliklinik Bonn, Germany

    H. Vetter, N. Fischer, J. -M. Bayer, Th. -E. Schmitz, C. Werning & W. Vetter

  2. Department für Innere Medizin Kantonsspital, Raemistr. 100, CH-8000, Zürich, Schweiz

    W. Vetter

Authors
  1. H. Vetter
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. Fischer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. -M. Bayer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Th. -E. Schmitz
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. Werning
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. W. Vetter
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vetter, H., Fischer, N., Bayer, J.M. et al. Aldosteron, Cortisol und Plasma-Renin-Aktivität beim Phäochromocytom. Klin Wochenschr 52, 719–721 (1974). https://doi.org/10.1007/BF01469334

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01469334

Key words

Schlüsselwörter

Search

Navigation