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Die Lipotropine

The lipotropins

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Summary

Two lipid mobilizing peptides (lipotropins) which are lipolytically active in 10 species have been isolated from pituitaries of sheep, pig, bovine, and man. The amino acid composition of 15 lipotropins has been investigated, the primary structure is known in three of them. This demonstrates that the lipotropins are different from the known pituitary hormones. Containing the sequence of β-MSH, they have a strong melanocyte stimulating activity. Until now, one can only speculate whether adrenocorticotrophic activity, which differs from one to the other lipotropin, is due to contamination or to the primary structure because of the heptapeptide which they have in common with ACTH. Other pituitary hormone activities are minimal or absent.

Via activation of adenylate cyclase and possibly inhibition of phosphodiesterase activity lipotropin is active in intact adipose tissue as well as in isolated fat cells. The stimulation of cyclo-AMP-system is calcium-dependent; in vivo hypocalcaemia and calcium ion influx into adipose tissue could be demonstrated. There is evidence for a simultaneous lipogenetic action of the lipotropin molecule. Further biological actions are hyperglycaemia, activation of the coagulation system, an insulinotropic and possibly glucagonotropic effect.

In the rabbit, lipotropins induce specific antibodies which completely inhibit the lipolytic action of these polypeptides. For ovine β-lipotropin a sensitive and specific radioimmunoassay has been developed, showing a β-lipotropin concentration in sheep serum of 10 ng/ml.

The following characteristics are in favour for the existence of a special lipid-mobilizing hormone:

  1. 1)

    the primary structure different from that of the known pituitary hormones,

  2. 2)

    the specific radioimmunoassay,

  3. 3)

    the wide species spectrum of lipolytic activity which is different from that of other pituitary hormones.

Zusammenfassung

Aus Hypophysen vom Schaf, Schwein, Rind und vom Menschen wurden zwei Polypeptide isoliert, die eine zum Teil ausgeprägte lipolytische Wirkung bei zahlreichen Spezies entfalten. Diese als Lipotropine bezeichneten Peptide wurden in 3 Fällen in ihrer Primärstruktur aufgeklärt; von weiteren liegen Angaben über die Aminosäurenzusammensetzung und erste Untersuchungen zur Sequenz vor. Danach unterscheiden sich die Lipotropine von den etablierten Hypophysenhormonen. Ihre Prüfung auf andere Hormonaktivitäten ergab bis auf MSH und zum Teil auch ACTH keine nennenswerten Aktivitäten; die Strukturgemeinsamkeiten zwischen den genannten Polypeptiden könnten eine Erklärung dafür sein.

Erfolgsorgan ist das Fettgewebe, der Wirkungsmechanismus läuft über das Cyclo-AMP-System, wobei eine eindeutige Calciumabhängigkeit besteht. Es liegen Anhaltspunkte für eine gleichzeitige lipogenetische Wirkung der Lipotropine vor. An weiteren biologischen Wirkungen wurden Hyperglykämie, ein insulinotroper Effekt, Hypocalcämie und Gerinnungsaktivierung beschrieben.

Mit Lipotropinen lassen sich spezifische Antikörper erzeugen, die in kleinen Konzentrationen die lipolytische Wirkung aufheben. Weiter konnte für β-LPH vom Schaf eine radioimmunologische Nachweismethode entwickelt werden, mit der beim Schaf eine Lipotropin-Serumkonzentration von 10 ng/ml festgestellt wurde. Erste Untersuchungen über die Lokalisation der lipolytischen, lipogenetischen und antigenen Aminosäurensequenz liegen vor.

Für die Existenz eines speziellen lipidmobilisierenden Hormons sprechen also:

  1. 1

    Die von den bekannten Hypophysenhormonen unterschiedliche Primärstruktur,

  2. 2

    die spezifische radioimmunologische Nachweismethode,

  3. 3

    das breite Speziesspektrum der lipolytischen Wirksamkeit, das sich von dem der anderen Hypophysenhormone unterscheidet.

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Schwandt, P. Die Lipotropine. Klin Wochenschr 52, 153–165 (1974). https://doi.org/10.1007/BF01614390

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