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Effect of propranolol and prindolol on renin secretion in normal supine man

Episodische Reninsekretion bei liegenden Normalpersonen unter Propranolol und Prindolol

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Zusammenfassung

Um den Effekt von Propranolol und Prindolol auf die Reninsekretion zu untersuchen, wurde unter natriumarmer Ernährung bei 10 liegenden Normalpersonen in kurzen Zeitabständen über Nacht die Plasma-Renin-Aktivität (PRA) bestimmt. 4 Personen standen unter einer 4tägigen Behandlung mit Propranolol, 3 wurden über denselben Zeitraum mit Prindolol behandelt und 3 Personen dienten als Kontrollgruppe.

Bei Normalpersonen zeigte Renin sowohl eine episodische Sekretion als auch einen typischen Nacht-Tag-Rhythmus. Unter Propranolol und Prindolol wurden Sekretionsepisoden des Renins entweder nicht beobachtet oder traten seltener auf. Eine Nacht-TagSchwankung der Reninsekretion war mit einer Ausnahme nicht zu beobachten. Unter beiden Betablockern war die mittlere PRA signifikant niedriger als bei Kontrollpersonen (p<0.001).

Unsere Ergebnisse zeigen, daß Propranolol und Prindolol die Renin-Aktivität senken und entweder die episodische Reninsekretion aufheben oder zu einer Frequenzabnahme der Sekretionsepisoden führen. Unsere Resultate erlauben die Schlußfolgerung, daß das sympathische Nervensystem eine bedeutende Rolle in der Steuerung der Nacht-Tag-Rhythmik und in der Regulation der Kurz-ZeitSchwankungen der Reninsekretion spielt.

Summary

To investigate the effect of propranolol and prindolol on renin secretion plasma renin activity (PRA) was determined overnight at short-time intervals in 10 sodium-restricted normal supine subjects. 4 of them were on a 4-days medication with propranolol, 3 were treated with prindolol and 3 were used as control group.

In normal controls renin was secreted episodically and showed characteristic night-day variations. Both in propranolol and in prindolol-treated subjects secretory episodes in renin secretion either did not occur or were less frequent than in normal controls. With one exception night-day variations in renin secretion were not observed. Mean PRA values were significantly lower than in the control group (p<0.001).

Our results show that both propranolol and prindolol lower PRA and eliminate or reduce the frequency of secretory episodes. It is concluded that the sympathetic nervous system plays an important role in regulating night-day variations and short-time fluctuations of renin secretion in normal supine man.

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Authors and Affiliations

  1. Department of Medicine, Kantonsspital, University of Zürich, Switzerland

    W. Vetter, H. Armbruster, R. Beckerhoff, J. Nussberger, U. Schmied, G. Reck, A. Fontana & W. Siegenthaler

  2. Hemodialysis-Unit, Stadtspital Waid, Zürich, Switzerland

    K. Záruba

  3. Medizinische Poliklinik, University of Bonn, Germany

    H. Vetter

Authors
  1. W. Vetter
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  2. K. Záruba
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  3. H. Armbruster
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  4. R. Beckerhoff
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  5. H. Vetter
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  6. J. Nussberger
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  7. U. Schmied
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  8. G. Reck
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  9. A. Fontana
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  10. W. Siegenthaler
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Vetter, W., Záruba, K., Armbruster, H. et al. Effect of propranolol and prindolol on renin secretion in normal supine man. Klin Wochenschr 53, 709–711 (1975). https://doi.org/10.1007/BF01468701

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  • DOI: https://doi.org/10.1007/BF01468701

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