Summary
The level of plasma postheparin-diamine oxidase was determined in two patients three days after an anaphylactic shock and was controlled four weeks, and also six months later. A decrease of the enzyme levels to about 10% of a control group was found and a slow enzyme increase to about 40% observed six months later. It seems probable that in anaphylaxis a depletion of the enzyme in liver and small intestine occurs as could be shown in animals after heparin load.
Zusammenfassung
Die Postheparin-Diamino-Oxidase wurde im Plasma bei zwei Patienten drei Tage nach einem anaphylaktischen Schock bestimmt und vier Wochen bzw. sechs Monate später kontrolliert. Ein Abfall des Enzymspiegels auf ca. 10%, verglichen mit einer Kontrollgruppe, wurde festgestellt, und ein langsamer Wiederanstieg der Enzymaktivität bis auf etwa 40% der Kontrollen wurde nach sechs Monaten gefunden. Wahrscheinlich erfolgt in der Anaphylaxie eine Enzymverarmung der Leber und des Dünndarmes, wie dies nach Heparinbelastung bei Normaltieren bekannt ist.
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Gäng, V., Gaubitz, W. & Gunzer, U. Postheparin-diamine oxidase (histaminase) in anaphylaxis. Klin Wochenschr 53, 285–287 (1975). https://doi.org/10.1007/BF01469122
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DOI: https://doi.org/10.1007/BF01469122