Zusammenfassung
Bei 8 Normotonikern sowie bei 8 Patienten mit essentieller Hypertonie wurden die Konzentrationen der Gesamtkatecholamine und die Aktivität der Dopamin-β-Hydroxylase (DBH) im Plasma unter Ruhebedingungen und während körperlicher Belastung gemessen. Bei den Hypertonikern waren die Ruhewerte der Katecholamine signifikant höher als bei den Normotonikern, während die DBH-Aktivität unter diesen Bedingungen bei beiden Gruppen gleich war. Bei einer Ergometerbelastung von 150 Watt stiegen die Katecholaminspiegel und die DHB-Aktivität bei den Hochdruckkranken stärker an als bei den Probanden mit normalem Blutdruck. Aus den Untersuchungsergebnissen kann man schließen, daß bei Patienten mit essentieller Hypertonie eine erhöhte Aktivität sympathischer Nerven besteht.
Summary
In 8 normotensive subjects and in 8 patients with essential hypertension total catecholamine content and dopamine-β-hydroxylase (DBH) activity in plasma were measured at rest and during physical exercise. Catecholamine levels at rest were significantly higher in the hypertensive than in the normotensive persons whereas the 2 groups of subjects did not differ in DBH activity at rest. At a work load of 150 watts there was a more pronounced increase of the catecholamine concentrations and of the DBH activity in the hypertensive patients than in the normotensives. One may conclude from the data that there is an increased sympathetic nerve activity in patients with essential hypertension.
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Dedicated to Professor Dr. med. P. Schölmerich to his 60th birthday
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Planz, G., Gierlichs, H.W., Hawlina, A. et al. A comparison of catecholamine concentrations and dopamine-β-hydroxylase activities in plasma from normotensive subjects and from patients with essential hypertension at rest and during exercise. Klin Wochenschr 54, 561–565 (1976). https://doi.org/10.1007/BF01619571
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DOI: https://doi.org/10.1007/BF01619571