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T cell type immunoblastic sarcoma diagnosed primarily by CSF cell membrane features

Immunoblastisches Sarkom vom T-Zell-Typ, diagnostiziert durch Oberflächen-Rezeptoren-Darstellung an Tumorzellen im Liquor cerebrospinalis

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Zusammenfassung

Es wird über ein immunoblastisches Sarkom vom T-Zell-Typ (Retikulosarkom) bei einer 65jährigen Frau berichtet. Bei der Obduktion fanden sich Tumorzellinfiltrate mit den typischen histomorphologischen Kriterien eines immunoblastischen Sarkoms im Uterus, im Knochenmark und in den Leptomeningen. Intra vitam wurde die Diagnose eines T-Zell-Lymphoms durch Anwendung immunologischer Marker an Zellen des Liquor cerebrospinalis gestellt. Soweit übersehbar, wurde bisher nur ein einziger Fall eines immunoblastischen Sarkoms vom T-Zell-Typ beschrieben.

Summary

The case of a 65 year-old female with an immunoblastic sarcoma of T cell type (reticulosarcoma) is reported. Post mortem tumor cell infiltrations with the typically histomorphological criteria of an immunoblastic sarcoma were found in the uterus, bone marrow and leptomeninges. With the aid of immunological markers the T cell type of this malignant lymphoma was diagnosed intra vitam on the basis of CSF cells. Until now, only one case of an immunoblastic sarcoma of the T cell type has been described in the literature.

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References

  1. Bentwich, Z., Kunkel, H.G.: Specific properties of human B and T lymphocytes and alteration in disease. Transplant. Rev.16, 29–50 (1973)

    PubMed  Google Scholar 

  2. Bianco, C., Patrick, R., Nussenzweig, V.: A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization. J. exp. Med.132, 702–720 (1970)

    PubMed  Google Scholar 

  3. Brouet, J.C., Labaume, S., Seligman, M.: Evaluation of T and B lymphocyte membrane markers in human non-Hodgkin malignant lymphomata. Brit. J. Cancer31, Suppl. II, 121–127 (1975)

    PubMed  Google Scholar 

  4. Catovsky, D.: T-cell origin of acid-phosphatase positive lymphoblasts. LancetII, 327–328 (1975)

    Google Scholar 

  5. Huber, H., Douglas, S.D.: Receptors sites on human monocytes for complement. Binding of red cells sensitized by cold antibodies. Brit. J. Haemat.19, 19–26 (1970)

    PubMed  Google Scholar 

  6. Jellinger, K., Radaskiewicz, T., Slowik, F.: Primary malignant lymphomas of the central nervous system in man. Acta neuropath. (Berl.) Suppl.VI, 95–102 (1975)

    Google Scholar 

  7. Lennert, K.: Morphology and classification of malignant lymphomas and so-called reticuloses. Acta neuropath. (Berl.) Suppl.VI, 1–16 (1975)

    Google Scholar 

  8. Lennert, K., Stein, H., Kaiserling, E.: Cytological and functional criteria for the classification of malignant lymphoma. Brit. J. Cancer31, Suppl. II, 29–59 (1975)

    PubMed  Google Scholar 

  9. Lukes, R.J., Collins, R.D.: New approaches to the classification of the lymphomata. Brit. J. Cancer31, Suppl. II, 1–28 (1975)

    Google Scholar 

  10. Oehmichen, M.: Cerebrospinal Fluid Cytology. Stuttgart: G. Thieme Publ. 1976

    Google Scholar 

  11. Oehmichen, M., Huber, H.: Möglichkeiten diagnostischer Zusatzuntersuchungen an Zellen des Liquor cerebrospinalis. Differenzierung mononukleärer Zellen des Liquors unter Verwendung immunologischer Marker. J. Neurol. (In press)

  12. Stein, H., Lennert, K., Parwaresch, M.R.: Malignant lymphomas of B-cell type. Lancet II, 855–857 (1972)

    Google Scholar 

  13. Tindle, B.H., Parker, J.W., Lukes, R.J.: “Reed Sternberg cells” in infectious mononucleosis? Amer. J. clin. Path.58, 607–613 (1972)

    Google Scholar 

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These studies were supported by a grant from the Deutsche Forschungsgemeinschaft

The skillful technical assistance of Mrs. Genčić is gratefully acknowledged

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Oehmichen, M., Gärtner, H.V. & Knittel-Jung, U. T cell type immunoblastic sarcoma diagnosed primarily by CSF cell membrane features. Klin Wochenschr 55, 37–40 (1977). https://doi.org/10.1007/BF01469782

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