Zusammenfassung
Bei chronisch niereninsuffizienten Ratten (5/6-Nephrektomie) wurden die intrazellulären Histidin-Konzentrationen verschiedener Organe (Gehirn, Skelettmuskel und Leber) bestimmt. Als Vergleichsgruppen dienten gesunde Kontroll-Ratten sowie sog. „pair-fed“ Ratten, die entsprechend den niereninsuffizienten Tieren eine verminderte Nahrungsmenge zu sich nahmen. Während sich in den untersuchten Gruppen die Plasma-Histidin-Konzentration nicht unterschied, war Histidin im Gehirn der chronisch niereninsuffizienten Tiere signifikant erhöht. Dieser Konzentrations-Anstieg dürfte als urämie-spezifisch anzusehen sein, da die entsprechend minderernährten Kontrolltiere keine Alteration zeigten. Als Ursache ist in erster Linie eine cerebrale Störung des Histidin-Metabolismus zu diskutieren.
Summary
Intracellular histidine levels were determined in brain, striated muscle and liver of rats with chronic renal insufficiency (5/6-nephrectomy) and compared both with normal rats and food-restricted (pair-fed) animals. There was no difference in plasma histidine concentration of the three groups whereas in the brain of the uremic rats histidine was significantly increased. Since there existed no alteration of the cerebral histidine in the corresponding pair-fed group, the finding of a raised histidine level in the renal insufficient rats seems to be due to a specific uremic disorder caused by a cerebral disturbance in histidine metabolism.
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Literatur
Bergström, J., Fürst, P., Josephson, B., Norée, L.-O.: Improvement of nitrogen balance in a uremic patient by the addition of histidine to essential amino acid solutions given intravenously. Life Sciences, Vol. 9, Part II, 787 (1970)
Bergström, J., Fürst, P., Josephson, B., Norée, L.-O.: Factors affecting the nitrogen balance in chronic uremic patients receiving essential amino acids intravenously or by mouth. In: Uremia. Ed. by R. Kluthe, G. Berlyne and B. Burton. Thieme, Stuttgart, p. 262 (1972)
Bergström, J., Fürst, P., Norée, L.-O., Vinnars, E.: The Effect of peritoneal dialysis on intracellular free amino acids in muscle from uremic patients. Proc. EDTA (Florence)9, 393 (1972)
Giordano, C., de Pascale, C., de Santo, N.G., Esposito, R., Cirillo, D., Stangherlin, P.: Disorder of metabolism of some amino acids. In: Uremia. Proc. IV. Int. Congress Nephr.2, 196 (1969)
Giordano, C., de Santo, N.G., Rinaldi, S., de Pascale, C., Pluvio, M.: Histidine and glycine essential amino acids in uremia. In: Uremia. Ed. by R. Kluthe, G. Berlyne and B. Burton. Thieme, Stuttgart p. 138 (1972)
Giordano, C., de Santo, N.G., Rinaldi, S., Acone, D., Esposito, R., Gallo, B.: Histidine supplements in the treatment of uremic anaemia. Proc. EDTA (Vienna)10, 160 (1973)
Held, E., Winkelmann, W., Finke, K., v. Dehn, H., Seyffart, G., Gurland, H.J.: Plasma-Aminosäuren bei chronischer Niereninsuffizienz. Klin. Wschr.52, 974 (1974)
Henkin, R.I., Patten, B.M., Re, P.K., Bronzert, D.A.: A Syndrome of acute zinc loss. Cerebellar dysfunction, mental changes, anorexia, and taste and smell dysfunction. Arch. Neur., Vol.32, 749 (1975)
Hennemann, H., Hevendehl, G., Horler, E., Heidland, A.: Toxic sympathicopathy in uremia. Proc. EDTA (Vienna)10, 166 (1973)
Josephson, B., Bergström, J., Fürst, P., Norée, L.-O.:15N-Studies on metabolism of urea, amino acids and protein in uremic patients. In: Uremia. Ed. by R. Kluthe, G. Berlyne and B. Burton. Thieme, Stuttgart p. 144 (1972)
Kopple, J.D., Wang, M., Vyhmeister, I., Baker, N., Swendseid, M.E.: Tyrosine metabolism in uremia. In: Uremia. Ed. by R. Kluthe, G. Berlyne and B. Burton. Thieme, Stuttgart p. 150 (1972)
Kult, J., Röckel, A., Hennemann, H., Heidland, A.: Bedeutung der L-Histidinsubstitution für den Proteinstoffwechsel (Transferrin und Komplementsystem) und die renale Anämie bei chronisch terminaler Niereninsuffizienz. Med. Klin.69, 1845 (1974)
Meister, A.: Biochemistry of amino acids. Ed. A. Meister. Acad. Press N.Y. p. 818 (1965)
Müting, D., Dishuk, B.D.: Free amino acids in serum, cerebrospinal fluid, and urine in renal disease with and without uremia. Soc. Exp. Biol. Med.126, 754 (1967)
Rippich, Th., Katz, N., Schaeffer, G., Schanz, M., Schinle, S., Südhoff, A., Zimmermann, W., Kluthe, R.: Detoxification and amino acid metabolism in chronic uremia: A therapeutic approach using biochemically defined liquid diets. In: Renal Insufficiency. Ed. by A. Heidland, Thieme, Stuttgart p. 174 (1976)
Schmid, G., Fricke, L., Hempel, K., Heidland, A.: Free amino acids in brain in experimental chronic renal failure. In press
Young, G.A., Parsons, F.M.: Plasma and urine amino acid imbalance in chronic renal failure. Proc. EDTA VII, p. 167 (1970)
Zimmermann, W., Whitehouse, S., Kluthe, R.: Aspects of histidine catabolism in uremia. In: Renal Insufficiency. Ed. by A. Heidland, Thieme, Stuttgart p. 185 (1976)
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Dedicated to Professor Dr. H.-W. Altmann on the occasion of his 60th birthday
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Schmid, G., Fricke, L., Lange, H.W. et al. Intracellular histidine content of various tissues (brain, striated muscle and liver) in experimental chronic renal failure. Klin Wochenschr 55, 583–585 (1977). https://doi.org/10.1007/BF01490512
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DOI: https://doi.org/10.1007/BF01490512