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Differentiation of lymphocytes in cerebrospinal fluid in disorders of the central nervous system

Differenzierung von lymphozyten im liquor cerebrospinalis bei verschiedenen ZNS-Erkrankungen

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Zusammenfassung

Bei 73 Patienten mit ZNS-Erkrankungen wurden im Liquor SIg-Lymphozyten und RF-Lymphozyten durch Nachweis von Oberflächenmarkern charakterisiert. Im Vergleich zu den Werten im Blut waren generell die SIg-Lymphozyten vermehrt, wogegen die RF-Lymphozyten vermindert waren. Darüber hinaus hatten Patienten mit akuten und chronischen Entzündungsprozessen vermehrt SIg-Lymphozyten. RF-Lymphozyten waren außer bei diesen Erkrankungen auch bei Malignomen erniedrigt. Ein Zusammenhang zwischen den Immunglobulinspiegeln und dem Gehalt an SIg-Lymphozyten im Liquor war nicht nachweisbar. Die erwähnten Verschiebungen lassen sich im Blut nicht nachweisen. Die Ergebnisse sprechen für eine vermehrte Stimulierbarkeit des humoralen Immunsystem im ZNS bei den erwähnten Erkrankungen.

Summary

In 73 patients with variable CNS-disorders Slg-lymphocytes and RF-lymphocytes originating from CF were characterized by demonstration of surface markers. In the CF the Slg-lymphocytes were increased in comparison to the blood whereas the RF-lymphocytes generelly were decreased. Patients suffering from acute or chronic inflammatory diseases had significantly more Slg-lymphocytes while RF-lymphocytes were significantly decreased in those patients as well as in patients with malignancies. A correlation between the number of Slg-lymphocytes and immunoglobulin-levels was not seen. The respective data in blood did not follow the changes in CF. The results suggest a prevailing stimulation of the humoral immune system of the CNS during inflammatory diseases.

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Scheiffarth, F., Teuber, J., Druschky, F. et al. Differentiation of lymphocytes in cerebrospinal fluid in disorders of the central nervous system. Klin Wochenschr 55, 903–906 (1977). https://doi.org/10.1007/BF01478826

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