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Gesteigerte Demethylierung von Aminophenazon unter antikonvulsiver Langzeitbehandlung

Increased demethylation of aminopyrine under long-term treatment with anticonvulsive drugs

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Summary

Demethylation of aminopyrine was measured in 25 healthy controls and 19 epileptics on long-term treatment with anticonvulsants by the14C-aminopyrine breath test. Compared to controls epileptics exhibited increased cumulative14CO2-exhalation rates (88.7% at 30 min, 62.6% at 2 h and 24.8% at 8 h) following ingestion of 2 µCi14C-aminopyrine.

The results suggest that long-term treatment with antiepileptic drugs results in increased demethylating function of the liver which can be easily detected by a simple breath analysis technique like decreased demethylation in chronic liver disease.

Zusammenfassung

Die Demethylierung von Aminophenazon wurde bei 25 Lebergesunden ohne Medikamenteneinnahme und 19 Epileptikern unter antikonvulsiver Langzeitbehandlung mittels des14C-Aminophenazon-Atemtestes untersucht. Im Vergleich zur Kontrollgruppe bestand bei Epileptikern unter antikonvulsiver Langzeitbehandlung eine gesteigerte Demethylierung für14C-Aminophenazon (kumulative14CO2-Exhalation: nach 1/2 h 88,7%, nach 2 h 62,6% und nach 8 h nur noch 24,8%). Der14C-Aminophenazon-Exhalationstest läßt sich nicht nur zur Erkennung einer verminderten Demethylierung der Leber bei chronischen Lebererkrankungen, sondern auch zur Erfassung einer gesteigerten Demethylierungsfunktion bei Patienten unter induzierenden Pharmaka verwenden.

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Authors and Affiliations

  1. Abteilung Gastroenterologie und Stoffwechselkrankheiten Medizinische Universitätsklinik Göttingen, Germany

    W. F. Caspary & J. Schäffer

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  1. W. F. Caspary
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  2. J. Schäffer
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Wesentliche Teile der Arbeit wurden von J. Schäffer im Rahmen einer Inaugural-Dissertation der Medizinischen Fakultät der Universität Göttingen durchgeführt

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Caspary, W.F., Schäffer, J. Gesteigerte Demethylierung von Aminophenazon unter antikonvulsiver Langzeitbehandlung. Klin Wochenschr 56, 677–679 (1978). https://doi.org/10.1007/BF01477022

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  • DOI: https://doi.org/10.1007/BF01477022

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