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Renal hypotension in sodium and fluid deprivation: Experimental findings in renin-depleted rats

Renale Hypotonie bei Natrium- und Flüssigkeitsentzug: Experimentelle Befunde bei Renin-verarmten Ratten

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Zusammenfassung

Eine arterielle Hypotonie renalen Ursprungs wurde als Folge einer niedrigen Plasma-Reninaktivität bei bestehendem Mangel an Natrium und extrazellulärer Flüssigkeit beobachtet. Als experimentelles Modell, an dem eine sekretorische Insuffizienz der Renin-produzierenden juxtaglomerulären Zellen und eine Natrium- und Volumenverarmung gleichzeitig erzeugt werden konnten, dienten vorher hypertone, Natrium- und Volumen-verarmte Ratten nach Entfernung der Drosselnieren und Zurücklassung der während der Hochdruckperiode Renin-verarmten contralateralen Nieren.

Es wird angenommen, daß sich eine renale Hypotonie nach akuten Verlusten von Natrium und extrazellulärer Flüssigkeit auch bei Patienten mit chronisch supprimiertem Renin-Angiotensin-System entwickeln kann.

Summary

Arterial hypotension of renal origin occurred as consequence of low plasma renin activity in the presence of sodium and extracellular fluid volume depletion. Secretory insufficiency of the renin-producing juxtaglomerular cells and sodium and volume deprivation, simultaneously, were achieved by removing the “clamped” kidneys in renal hypertensive, sodium- and volume-depleted rats leaving in situ the contralateral kidneys deprived of renin during the preceding period of hypertension.

It is suggested that renal hypotension after acute losses of sodium and extracellular fluid may also develop in patients with chronically depressed renin-angiotensin system.

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Authors and Affiliations

  1. Pathologisches Institut der Universität Tübingen, Germany

    U. Helmchen, H. Dienemann, U. Kneissler, R. Stahl & E. J. Kirchertz

  2. Institut de Pharmacologie de l'Université de Lausanne, Lausanne, Switzerland

    H. Dienemann, U. Kneissler, R. Stahl & E. J. Kirchertz

Authors
  1. U. Helmchen
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  2. H. Dienemann
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  3. U. Kneissler
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  4. R. Stahl
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  5. E. J. Kirchertz
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Helmchen, U., Dienemann, H., Kneissler, U. et al. Renal hypotension in sodium and fluid deprivation: Experimental findings in renin-depleted rats. Klin Wochenschr 56, 253–255 (1978). https://doi.org/10.1007/BF01477833

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