Zusammenfassung
Angiotensin II (ANG II) wurde spontan hypertensiven (SH) Ratten und normotensiven Wistar Kyoto (WK) Ratten in den lateralen Hirnventrikel (i.v.t.) infundiert. Der mittlere arterielle Blutdruck stieg bei den SH Ratten signifikant höher an als bei den normotensiven WK Ratten. Propranolol-Vorbehandlung reduzierte die Blutdruckanstiege nach i.v.t. ANG II Infusionen bei WK Ratten, nicht aber bei SH Ratten. Die höhere ANG II Empfindlichkeit der SH Raten bestätigt frühere Ergebnisse, die darauf hinweisen, daß zentrales ANG III an der Aufrechterhaltung des hohen Blutdruckes von SH Ratten beteiligt sein kann.
Summary
The blood pressure responses following infusions of angiotensin II (ANG II) into the brain ventricles (i.v.t.) have been tested in spontaneously hypertensive (SH) rats and in normotensive Wistar Kyoto (WK) rats. The mean arterial blood pressure increases were significantly higher in SH rats than in WK rats. Propranolol treatment reduced blood pressure increases to i.v.t. ANG II in WK, but not in SH rats. The higher sensitivity to i.v.t. ANG II in SH rats supports a role of central ANG II in the maintenance of high blood pressure in SH rats.
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References
Conway, J., Darwin, K., Hilditch, A., Loveday, B., Reeves, M.: Effect of propranolol on blood pressure in normal and hypertensive rats. Clin. Sci. Mol. Med.48, 101s-103s (1975)
Dietz, R., Schömig, A., Haebara, H., Mann, J.F.E., Rascher, W., Lüth, J.B., Grünherz, N., Gross, F.: Studies on the pathogenesis of spontaneous hypertension of rats. Circ. Res., in press (1978)
Finkielman, S., Fischer-Ferraro, C., Diaz, A., Goldstein, D.J., Nahmod, V.E.: A pressor substance in the cerebrospinal fluid of normotensive and hypertensive patients. Proc. Natl. Acad. Sci. (USA)69, 3341–3344 (1972)
Ganten, D., Fuxe, K., Phillips, M.I., Mann, J.F.E., Ganten, U.: The brain isorenin-angiotensin system. Biochemistry, localization and possible role in drinking and blood pressure regulation. In: Frontiers in Neuroendocrinology, Vol. 5, W.F. Ganong, L. Martin (eds.) pp. 61–91. New York, Raven Press 1978
Haack, D., Möhring, J.: Vasopressin-mediated blood pressure response to intraventricular injection of angiotensin II in the rat. Pflüger's Arch.373, 167–173 (1978)
Hoffman, W.E., Phillips, M.I., Schmid, P.G.: Central angiotensin II-induced responses in spontaneously hypertensive rats. Am. J. Physiol.232, H426-H433 (1977)
Hutchinson, J.S., Schelling, P., Möhring, J., Ganten, D.: Pressor action of centrally perfused angiotensin II in rats with hereditary hypothalamic diabetes insipidus. Endocrinology99, 819–823 (1976)
Mann, J.F.E., Phillips, M.I., Dietz, R., Haebara, H., Ganten, D.: Effects of central and peripheal angiotensin blockade in hypertensive rats. Am. J. Physiol.234, 629–637 (1978)
Phillips, M.I., Felix, D., Hoffman, W.E., Ganten, D.: Angiotensin sensitive sites in the brain ventricular system. In: Approaches to the Cell Biology of Neurons. Society for Neuroscience Symposia, Vol. II, W.M. Cowan, J.A. Ferrendelli (eds.), pp. 308–339. Bethesda, Society for Neuroscience, 1977
Reid, I.A.: Is there a brain renin angiotensin system? Circ. Res.41, 147–153 (1977)
Severs, W.B., Daniels-Severs, A.E.: Effects of angiotensin on the central nervous system. Pharmacol. Rev.25, 415–449 (1973)
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Johnson, A.K., Simon, W., Schaz, K. et al. Increased blood pressure responses to central angiotensin II in spontaneously hypertensive rats. Klin Wochenschr 56 (Suppl 1), 47–49 (1978). https://doi.org/10.1007/BF01477452
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DOI: https://doi.org/10.1007/BF01477452