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Zum gegenwärtigen Stand der internistischen Therapie des Mammacarcinoms

I. Hormonbehandlung — Wandlungen und Aussichten

Current status in the treatment of breast cancer

I. Endocrine management — Change of concepts and outlook for the future

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Summary

A renewal of interest in endocrine therapy of breast cancer is resulting from the demonstration of steroid hormone receptors in tumor cells sensitive to antiestrogens and the possibility for predicting endocrine responsiveness. Therefore new therapeutical concepts have been developed and some of the established endocrine regimens have been reduced to historical interest. It is more than doubtful that the present schematization in selecting the proper kind of endocrine treatment has any future as methodical difficulties in demonstrating hormone receptors will be overcome and the understanding of their biological function will increase.

Zusammenfassung

Die Hormontherapie des Mamma-Ca hat in jüngster Zeit durch den Nachweis von Hormonrezeptoren an den Tumorzellen und die gezielte Beeinflussung des Tumorwachstums durch kompetitive Hemmung der Rezeptoren mit Antiöstrogenen große Wandlungen erfahren. Einige der herkömmlichen hormonellen Maßnahmen haben nur noch historische Bedeutung, andere werden in Zukunft nicht mehr zur Anwendung gelangen. Ob mit einem methodisch verbessertem Nachweis und somit vertieftem Verständnis der Steroidhormonrezeptoren auf das Tumorwachstum das derzeit noch stark schematisierte Vorgehen bei der Auswahl der verschiedenen Therapieschritte zukünftig Bestand haben wird, ist fraglich.

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  1. Medizinische Klinik III — Großhadern, Universität München, Germany

    U. Jehn, H. Sauer & W. Wilmanns

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Jehn, U., Sauer, H. & Wilmanns, W. Zum gegenwärtigen Stand der internistischen Therapie des Mammacarcinoms. Klin Wochenschr 57, 913–920 (1979). https://doi.org/10.1007/BF01478547

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