Zusammenfassung
„Kontinuierliche Hämoperfusion“ (ca. 8 h täglich während 2–3 Wochen) wurde wegen Paraquatvergiftung an zwei Patienten durchgeführt, bei denen aufgrund der Höhe der Paraquat-Plasma-Spiegel mit der Entwicklung einer letalen Lungenfibrose gerechnet werden mußte. Beide Patienten konnten durch diese Maßnahme der „Kontinuierlichen Hämoperfusion“ gerettet werden. Beschichtete Aktivkohle scheint eine größere Affinität für Paraquat zu haben als die Lungen.
Summary
“Continuous hemoperfusion” (8 h/day for 2–3 weeks) was performed in two patients suffering from severe paraquat intoxication. On account of paraquat plasma concentrations a fatal outcome due to pulmonary fibrosis would have been expected in both cases. However, both patients survived following “continuous hemoperfusion” therapy. Coated activated charcoal seems to have a higher affinity for paraquat than lung tissue.
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A preliminary report has been presented. Okonek, S., Tönnis, H.J., Baldamus, C.A., Hofmann, A., Symposium Hemoperfusion, Dialysate and Diafiltrate Purification, Tutzing 1978
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Okonek, S., Baldamus, C.A., Hofmann, A. et al. Two survivors of severe paraquat intoxication by “continuous hemoperfusion”. Klin Wochenschr 57, 957–959 (1979). https://doi.org/10.1007/BF01478553
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DOI: https://doi.org/10.1007/BF01478553