Zusammenfassung
Nach einer einmaligen oralen Gabe von 4 mg/kg Indometacin kam es innerhalb von 4 h bei Natrium- und Volumenverarmten Ratten zu einem signifikanten Abfall der Plasma-Reninaktivität und des systolischen Blutdrucks.
Bei normalen Ratten führte die Indometacingabe lediglich zur Erniedrigung der Plasma-Reninaktivität ohne Beeinflussung des arteriellen Blutdruckes.
Es wird deshalb angenommen, daß Indometacin über eine Hemmung der Prostaglandinsynthese den Blutdruck stabilisierenden Effekt des Renin-Angiotensin-Systems bei Natrium- und Volumenverarmung, vermindern kann.
Summary
After a single oral dose of 4 mg/kg indomethacin (IDM) to sodium and volume depleted rats plasma renin activity (PRA) and systolic blood pressure fell significantly within four hours. In sodium repleted animals indomethacin did not change systolic blood pressure (BP) although plasma renin activity was decreased.
Thus, indomethacin by inhibition of prostaglandin synthesis may diminish the blood pressure maintaining effect of the stimulated renin-angiotensin system in sodium and volume depletion.
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Stahl, R., Dienemann, H., Kneissler, U. et al. Indomethacin induced hypotension in sodium and volume depleted rats. Klin Wochenschr 57, 143–145 (1979). https://doi.org/10.1007/BF01476055
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DOI: https://doi.org/10.1007/BF01476055