Summary
Plasma separation was carried out using a new cellulose diacetate hollow-fibre module. The pore size of the membranes used was 0.2 µm and the cut-off at approximately 3 million dalton. Five litres of filtrate was separated in 80 min. The protein content of the filtrate was 60% of that in the blood plasma. When plasma and filtrate were compared, there was little difference in the proportions of the immunoglobulins. At the end of treatment, the immunoglobulin content of the plasma had been reduced to 40% of its initial concentration.
Zusammenfassung
Die Plasmaseparation wurde mit Hilfe von Zellulose-Diacetat-Hohlfasermodulen durchgeführt. Die Porengröße der Membranen betrug 0.2 µm und hatte eine obere Ausschlußgrenze von ungefähr 3 Millionen Dalton. Fünf Liter Filtrat konnten durchschnittlich in 80 min separiert werden. Der Proteingehalt des Filtrates lag bei etwa 60% des Proteingehaltes im Blut. Die Realtionen der Immunglobuline unterschieden sich im Plasma und im Filtrat nur gering. Durch eine Plasmaseparation gelang es, die Konzentration an Immunglobulinen auf etwa 40% der initialen Konzentration zu senken.
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Literatur
Glöckner WM, Sieberth HG (1978) Plasma filtration, a new method of plasma exchange Proc Eur Soc Artif Organs (ESAO). 4:214–217
Inowe N, Yamazaki Z, Oda T, Sugiura M, Wada T, Fujisani Y, Hayano F (1977) Treatment of introtable ascites by continuous reinfusion of sterilized, cell-free, and concentrated ascites fluid. Trans Am Soc Artif Intern Organs 23:698
Mathieu P, Lambert PH, Mieschen PA (1974) Detection of antiglomerular basement membrane antibodies by radioimmunological technique. J Clin Invest 54:128
Ouchi KW, Piakiewicz M, Malchesky PS, Carey WD, Herman RE, Nosè Y (1978) An efficient, specific, and blood compatible sorbent system for hepatic Assist. Trans Am Soc Artif Intern Organs 24:246
Sanjo K, Fujimori Y, Yamazaki Z, Futagawa S, Ootsubo O, Ichihara S, Hidai K, Shima F, Saito M, Atsumi K, Sugiura M, Wada T, Inoue N, Fujiwara K, Kanai K, Sakai T, Oda T, Abe T, Sakurai T, Inagaki K, Kominami N (1976) The effect of liver support system (plasma perfusion detoxication) providing removal of plasma amino acids in patients with fulminant hepatitis. Artificial Organs (Japan) [Suppl] 5:231–234
Sieberth HG, Glöckner WM, Hirsch HH, Borberg H, Dotzauer G, Mahieu P (in press) Plasma separation by membranes. Vortrag ISAO, Kongreß New York 1979
Yamazaki Z, Fujimori Y, Sanjo K, Kojima Y, Sugiura M, Wada T, Inoue N, Hayashi K, Kanai K, Sakai T, Oda T, Saito M, Atsumi K, Sakurai T, Abe T, Inagaki K, Kominami N (1976) Clinical studies on new artificial liver support system (Plasma perfusion detoxication). Artificial Organs (Japan) [Suppl] 5:227–230
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Mit freundlicher Unterstützung durch das Bundesministerium für Forschung und Technologie, Bonn
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Sieberth, H.G., Glöckner, W., Hirsch, H.H. et al. Plasmaseparation mit Hilfe von Membranen — Untersuchungen am Menschen. Klin Wochenschr 58, 551–556 (1980). https://doi.org/10.1007/BF01477165
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DOI: https://doi.org/10.1007/BF01477165