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Effect of indomethacin on blood pressure in rats with renovascular hypertension: Dependence on plasma renin activity

Einfluß von Indometacin auf den Blutdruck in Ratten mit renovasculärer Hypertonie: Abhängigkeit von der Plasmareninaktivität

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Summary

The effect of the cyclooxygenase inhibitor indomethacin (3.4 mg/kg/24 hr) on systolic blood pressure (PB) and plasma-renin-activity (PRA) was evaluated in normotensive and renovascular hypertensive rats receiving either a normal or low salt diet. Indomethacin reduced PRA in normal and hypertensive animals on both low and normal salt intake. Indomethacin furthermore, decreased BP in animals on low sodium diet but increased PB in sodium repleted rats. These data suggest that the effect of indomethacin on rat BP may depend on the state of extracellular volume and PRA.

Zusammenfassung

Bei normotensiven und renal hypertensiven Ratten, die kochsalzarm oder kochsalznormal ernährt wurden, wurde der Effekt des Cyclooxygenasehemmers Indomethacin (3,4 mg/kg/24 h) auf den systolischen Blutdruck und die Plasma-Renin-Aktivität untersucht. Indometacin reduzierte die Plasma-Renin-Aktivität in kochsalzarm und kochsalznormal ernährten, normotensiven und hypertensiven Tieren. Darüberhinaus erniedrigte Indomethacin den systolischen Blutdruck in salz-arm ernährten Ratten, erhöhte jedoch den Blutdruck in salz-normal ernährten Tieren. Diese Befunde lassen vermuten, daß der Effekt von Indomethacin auf den Blutdruck von Ratten vom Extrazellulärvolumen und der Plasma-Renin-Aktivität abhängt.

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Authors and Affiliations

  1. Abteilung IV, Zentrum Innere Medizin, Universität Freiburg i. Br., Germany

    R. Stahl, H. Dienemann, K. Besserer, U. Kneissler & U. Helmchen

  2. Pathologisches Institut der Universität Göttingen, Germany

    R. Stahl, H. Dienemann, K. Besserer, U. Kneissler & U. Helmchen

Authors
  1. R. Stahl
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  2. H. Dienemann
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  3. K. Besserer
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  4. U. Kneissler
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  5. U. Helmchen
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Supported by Deutsche Forschungsgemeinschaft

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Stahl, R., Dienemann, H., Besserer, K. et al. Effect of indomethacin on blood pressure in rats with renovascular hypertension: Dependence on plasma renin activity. Klin Wochenschr 59, 245–246 (1981). https://doi.org/10.1007/BF01476582

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  • DOI: https://doi.org/10.1007/BF01476582

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