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Die Apolipoproteine

The apolipoproteins in man

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Summary

Twelve different apolipoproteins have been described in human serum. Apo A–I and apo A–II are essential for the structure of the HDL particles and for the function of LCAT activity. Apo B is the main protein in LDL but does also occur in the triglyceride-rich particles. Apo B represents the binding protein for the LDL-receptor pathway. The C-apolipoproteins are located on the surface of VLDL. They are transferred to HDL throughout the catabolism of VLDL and affect lipoprotein lipase activity. This enzyme is also affected by the E-apolipoproteins which occur in the triglyceride-rich particles as well as in HDL. Apo E is the binding site for another specific cell receptor. The concentration and metabolism of apolipoproteins is affected by diet, drugs, hormones, body weight, alcohol, cigarettes, physical exercises, liver and renal diseases. There is a close relation between apolipoproteins and atherosclerosis.

Zusammenfassung

Im Humanserum sind bisher zwölf verschiedene Apolipoproteine nachgewiesen worden. Apo A–I and Apo A–II sind Strukturproteine der HDL und haben Coenzymfunktion für die LCAT. Apo B ist Hauptprotein der LDL, kommt aber auch in den triglyceridreichen Lipoproteinen vor und ist verantwortlich für die LDL-Rezeptorbindung. Die C-Apolipoproteine sind Oberflächenproteine der VLDL und werden bei deren Abbau auf die HDL übertragen; gleichzeitig haben sie spezifische Wirkungen auf die Lipoproteinlipase. Diese wird auch von den E-Apolipoproteinen beeinflußt, die sowohl in triglyceridreichen Lipoproteinen wie HDL vorkommen und für die Lipoproteinbindung an einen weiteren Zelloberflächenrezeptor verantwortlich sind. Ernährung und Medikamente, Hormone und Körpergewicht, Alkohol, Zigarettenrauchen und körperliches Training und schließlich Erkrankungen von Leber und Nieren beeinflussen Konzentration und Stoffwechsel der Apolipoproteine. Abschließend werden die Zusammenhänge mit der Arteriosklerose beim Menschen besprochen.

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Schwandt, P. Die Apolipoproteine. Klin Wochenschr 60, 637–649 (1982). https://doi.org/10.1007/BF01716796

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