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Mechanism of histamine release from rat peritoneal mast cells

Mechanismen der Histaminfreisetzung aus Peritonealmastzellen der Ratte

  • 2. Mechanisms Of Adverse Reactions And Histamine Release In Anaesthesia And Surgery
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Summary

The present communication endeavours to elucidate the mechanism of histamine release from rat peritoneal mast cells induced by selective histamine liberators.

Of the different enzymatic processes involved in secretion the following are considered: ecto-ATPase activity in the mast cell, pro-esterase-esterase conversion during histamine secretion, cyclic AMP and microtubule association/dissociation, phospholipase A2 and the effect of phospholipid metabolites on secretion, N-methyl transferase and the methylation of phospholipids and the phosphorylation and desphosphorylation of proteins.

Zusammenfassung

In dieser Arbeit wird versucht, die Mechanismen der Histaminfreisetzung aus Peritonealmastzellen der Ratte mit Hilfe selektiver Histaminliberatoren zu klären.

Von den verschiedenen enzymatischen Mechanismen, die an der Sekretion beteiligt sind, werden folgende Prozesse im Detail betrachtet: die Ecto-ATP-ase Aktivität in der Mastzelle, die Proesterase-Esterase-Umwandlung während der Histaminsekretion, das cyclische AMP und die Mikrotubuli Assoziation/Dissoziation, die Phospholipase A2 und der Effekt von Phospholipidmetaboliten auf die Sekretion, die N-Methyltransferase und Methylierung von Phospholipiden und die Phosphorylierung und Dephosphorylierung von Proteinen.

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  1. Novo Research Institute, Novo Allé, DK-2880, Bagsvaerd, Denmark

    S. A. Patkar & B. Diamant

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  1. S. A. Patkar
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  2. B. Diamant
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Patkar, S.A., Diamant, B. Mechanism of histamine release from rat peritoneal mast cells. Klin Wochenschr 60, 948–953 (1982). https://doi.org/10.1007/BF01716953

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