Summary
Antibodies of the IgG class possess antibacterial, antiviral and toxin neutralizing properties and for this reason are administered prophylactically and therapeutically. In the case of the immunoglobulin preparations commercially available for i.v. application a basic distinction must be made between unsplit immunoglobulins and those antibody preparations obtained by enzymatic digestion, such as F(ab')2 or Fab antibodies. This survey deals with the largely experimental evidence describing the biological properties of these preparations. Administration of antibodies in the presence of the corresponding antigens leads to the formation of immune complexes in the organism. These immune complexes can activate, either directly or indirectly, the cellular and humoral systems which are involved in phagocytosis and the elimination of antigens, in the regulation of the body's own antibody production and in inflammatory reactions. As a result of their inability to interact with Fc receptors, immune complexes with F(ab')2 or F(ab) antibodies appear to be less active in the release of inflammation mediators from leucocytes and thrombocytes than immune complexes with unsplit immunoglobulins. These, on the other hand, can antigen-specifically and non-antigenspecifically suppress the immune system which is not the case for immune complexes with F(ba')2 or Fab antibodies. There are indications that these split products also occur in vivo due to the action of tissue and leucocyte proteases. Unlike Fab prcparations, F(ab')2 antibodies have antibacterial and antiviral potencies similar to unsplit immunoglobulins, which is probably due to the ability of F(ab')2 molecules to activate complement, not by the classical but by the alternative pathway. Like Fab preparations, F(ab')2 molecules appear to be superior to unsplit IgG in the elimination of haptens. On account of the relatively long period of time unsplit immunoglobulins remain in the blood, they are well suited for prophylactic treatment and substitution over longer periods. The extent to which indications, obtained predominantly from experimental studies, of a reduced release of inflammation mediators, a lack of immune suppression and a lack of augmentation of IgG catabolism would advocate the use of F(ab')2 split products, especially for therapeutic purposes, can only be ascertained after prospective and comparative studies have been carried out.
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Abbas AK, Klaus GGB (1978) Antigen-antibody complexes suppress antibody production by mouse plasmacytoma cells in vitro. Eur J Immunol 8:217
Alarcon-Segovia D, Ruiz-Argüelles A (1979a) Antibody penetration into living cells. A new mechanism of immunologically mediated damage. Rev Invest Clin 31:111
Alarcon-Segovia D, Ruiz-Argüelles A, Fishbein E (1978) Antibody to nuclear ribonucleoprotein penetrates live human mononuclear cells through Fc receptors. Nature 271:67
Alarcon-Segovia D, Ruiz-Argüelles A, Fishbein E (1979b) Antibody penetration into living cells. I. Intranuclear immunoglobulin in peripheral blood mononuclear cells in mixed connective tissue disease and systemic lupus erythematosus. Clin Exp Immunol 35:364
Alarcon-Segovia D, Ruiz-Argüelles A, Llorente L (1979c) Antibody penetration into living cells. II. Anti-ribonucleoprotein IgG penetrates into Tγlymphocytes causing their deletion and the abrogation of suppressor function. J Immunol 122:1855
Albar JP, Juarez C, Vivanco-Martinez F, Bragado R, Ortiz F (1981) Structural requirements of rabbit IgG F(ab')2 fragment for activation of the complement system through the alternative pathway. I. Disulfide bonds. Mol Immunol 18:925
Amiraian K, Leikhim EJ (1961) Interaction of fragment III of rabbit gammaglobulin and guinea-pig complement. Proc Soc Exp Biol Med 108:454
Arlt HG (1940) Diphtherie-Fermoserum. Münch Med Wochenschr 26:696
Ax W, Kanzy EJ, Seiler FR (1981) In vivo phagocytosis: Enhancement of bacterial clearence by native and enzymetreated immunoglobulins. Immunobiology 159 (4/5): 349
Barandun S (1964) Die Gammaglobulintherapie. Chemische, immunologische und klinische Grundlagen. Bibl Haematol 17:1
Bauer HW, Bertling J, Romen W (1979) In vivo Studie zur Wirksamkeit der IV Immunglobulintherapie. Fortschr Med 97:475
von Behring E, Kitasato S (1890) Über das Zustandekommen der Diphtherie-Immunität und der Tetanus-Immunität bei Tieren. Dtsch Med Wochenschr 49:1113
Berken A, Benaceraf B (1966) Properties of antibodies cytophilic for macrophages. J. Exp Med 123:119
Beyer JH, Klee M, Kaboth U, Kehl A, Köstering H, Krieger G, Nagel GA (1980) Probleme der Ersatzlösungen, Gammaglobulinsubstitution und Tumorenhancement bei Plasmaphercsen von Tumorpatienten. Symp. über Plasmaaustauschbehandlung in der Immunologie und Onkologie, Göttingen
Bianco C, Griffin FM, Silverstein SC (1975) Studies of the macrophage complement receptors. J Exp Med 141:1278
Bocci V (1976) Catabolism of Plasma Proteins. In: Allison AC (ed) Structure and function of plasma proteins, Vol. 2. Plenum Publishing Corporation, New York
Butler VP Jr, Schmidt DH, Smith TW, Haber E, Raynor BD, Demartini P (1977) Effects of sheep-digoxin-specific antibodies and their Fab-fragments on digoxin pharmacokinetics in dogs. J Clin Invest 59:345
Bystryn JC, Graf MW, Uhr JW (1970) Regulation of antibody formation by serum antibody. II. Removal of specific antibody by means of exchange transfusion. J Exp Med 132:1279
Carter CA, Easty DL (1981) Experimental ulcerative herpetic keratitis. III. Evaluation of hyperimmune gammaglobulin therapy. Br J Ophthalmol 65:392
Cerottini JC, McConahey PJ, Dixon FJ (1969) The immunosuppressive effect of passively administered antibody IgG fragments. J Immunol 102:1008
Dethlefsen J, Stübner G (1980) Die Verteilung von Immunglobulinen im Pcritonealexsudat bei diffuser Peritonitis. 126. Norddeutscher Chirurgen-Kongress, Hamburg
Duswald KH, Müller K, Seifert J, Ring J (1980) Wirksamkeit von i.v.-Gammaglobulin gegen bakterielle Infektionen chirurgischer Patienten. Münch Med Wochenschr 122:832
Eckert P, Schneider M, Naber M (1980) Beitrag zur Effektivität der Immunglobuline bei der experimentellen Peritonitis. Langenbecks Arch Chir 351:63
Ehrnst AC (1977) Complement activation by measles virus cytotoxic antibodies: Alternative pathway C activation by hemagglutination-inhibition antibodies but classical activation by hemolysin antibodies. J Immunol 118:533
Ehrnst AC (1978) Separate pathways of C activation by measles virus cytotoxic antibodies: Subclass analysis and capacity of F(ab')2 molecules to activate C via the alternative pathway. J Immunol 121:1206
Eibl M, Friers G (1978) Hemmung der Opsonisierung von E. coli durch cnzymatisch gespaltene Gammaglobuline. Wien Klin Wochenschr 90:718
Enokidani N, Mizukoshi M, Wada S, Sugisaki Y, Hirayama Y (1981) Distribution and permeability of pepsin-treated human immunoglobulin preparation (Globulin-V) to tissues. The Clin Report 15:3001
Ewald RW (1979) Prophylaxe und Therapie mit IV-applizierbarem Immunglobulin: Indikationen. Pharmazeutische Zeitung 124:847
Fahey JL, Robinson AC (1963) Factors controlling serum gammaglobulin concentration. J Exp Med 118:845
Fateh-Moghadam A, Besinger U, Geursen RG (1982) Ein klinisches Modell zur Regulation der humoralen Immunantwort. Proc. Heidelberger Immunglobulin-Symposium. In: Infusionstherapie und Klin. Ernährung, “Sonderband”, Karger-Verlag
Fearson DT, Austen KF (1980) The alternative pathway of complement — A system for host resistance to microbial infection. N Engl J Med 203:259
Fehr K, Velvart M, Watanabe H, Boeni A (1974) Digestion of autologous IgG by acid lysosomal protease (cathepsin D) and its role in immune complex formation and inflammation. Adv Clin Pharmacol 6:64
Forni L, Coutinho A, Köhler G, Jerne NK (1980) IgM antibodies induce the production of antibodies of the same specificity. Proc Natl Acad Sci USA 77:1125–1128
Gadd JK, Reid KBM (1981) Importance of the integrity of the inter-heavy-chain disulfide bond of rabbit IgG in the activation of the alternative pathway of human complement by the F(ab')2 region of rabbit IgG antibody in immune aggregates. Immunology 42:75
Ghetie V, Mota C (1971) Catabolism of rabbit immunoglobulin G by some cathepsin-rich subcellular fractions isolated from rat liver. Immunochemistry 8:89
Ghetie V, Sulica A (1970) Uptake and breakdown of rabbit immunoglobulin G by guinea pig peritoneal polymorphonuclear leukocytes. Immunochemistry 7:175
Gronski P, Seiler FR (1983) Spezifische Serumtherapie gestern und heute, Teil 1/Teil 2. Fortschr Med 4:103 u. 6:199
Haakenstad AO, Mannik M (1976) The disappearance kinetics of soluble immune complexes prepared with reduced and alkylated antibodies in mice. Lab Invest 35:283
Haakenstad AO, Mannik M (1977) The biology of immune complexes. In: Talal N (ed) Autoimmunity. Academic Press, New York, pp 277
Henson PM (1971) Interaction of cells with immune complexes: Adherence release of constituents and tissue injury. J Exp Med 134:114
Henson PM, Spiegelberg HL (1973) Release of serotonin from human platelets induced by aggregated immunoglobulins of different classes and subclasses. J Clin Invest 52:1282
Hess, T, Stucki P, Scholtysik G, Riesen W (1979) Antikörperbehandlung einer Digoxin-Intoxikation bei einem Patienten mit Niereninsuffizienz. Dtsch Med Wochenschr 104:1273
Hoffmann MK, Kappler JW (1978) Two distinct mechanisms of immune suppression by antibody. Nature 272:64
Hofstaetter T, Brammsen H, Gronski P, Sedlacek HH, Seiler FR (1981) Activation of human neutrophils by immune complexes and IgG aggregates. Immunobiol 159:283
Horwitz MA (1980) The roles of the Fc and C3 receptors in the phagocytosis and killing of bacteria by human phagocytes. J Reticuloendothel Soc 28:Suppl, 17
Ignarro LJ (1974) Regulation of lysosomal enzyme secretion. Role in inflammation. Agents and Actions 4:241
Ishibashi Y, Sunagawa K, Oikawa T, Kuratsuji T, Sirai Y, Minamisato S, Yamashita N, Akita H, Hotta M, Shirozaki K (1980) The effects of pepsin-treated human normal immunoglobulin preparation against experimental infections with E. coli or Ps. aeruginosa. Jap J Pediat 33:483
Isliker H, Jacot-Guillarmod H, Waldesbuhl M, Fellenberg RV (1967) Complement fixation by different IgG preparations and fragments. In: Miescher PA, Grabar P (eds) Immunopathology. Vth Int Symp Mechanisms of inflammation induced by immune reaction, Grune and Stratton, New York, pp 197
Israels ED, Nisli G, Paraskevas F, Israels LG (1973) Platelet Fc receptor as a mechanism for Ag-Ab complex-induced platelet injury. Thromb Haemostas 29:434
Jackson DC, Grant CK (1976) Tumor cell lysis mediated by IgG or F(ab')2 antibody fragments and complement. Immunochemistry 13:721
Johannsen R, Enders B, Seiler FR (1977) Hemolytic and lympholytic properties of F(ab')2 fragments of antibodies: Activation via the alternate pathway. Z Immunol Forsch 153:313
Johannsen R, Kanzy EJ, Seiler FR (1980) Involvement of the alternative pathway of complement activation as a function of antibody concentration in hemolytic and lympholytic systems. Immunobiol 157:197
Johannsen R, Kanzy EJ, Ackermann O, Barth R, Bengelsdorff HJ, Hinz J, Weinmann E, Gruschkau H, Seiler FR (1982) Schutzwirkung von unmodifizierten und S-sulfonierten 7S-Antikörpern bei vier verschiedenen, experimentellen Virusinfektionen. Beitr Infusionstherap Klin Ernähr 9:141
Johnson PM, Page-Faulk W (1976) Rheumatoid Factor: Its Nature, Specificity and Production in Rheumatoid Arthritis. Clin Immunol Immunopathol 6:414
Juarez C, Albar JP, Vivanco-Martinez F, Bragado R, Ortiz F (1981) Structural requirements of rabbit IgG F(ab')2 fragment for activation of the complement system through the alternative pathway-II. Ionic and indole groups. Molec Immunol 18:935
Kaneko K, Suehiro T, Shibata Y (1981) An in vivo study concerning distribution of human immunoglobulins to the tissues of rats. Med Consultation New Remedies 18:1393
Kitagawa H, Okumura K (1980) Blood half life and in vivo distribution of IV-immunoglobulin preparations. The Clin Report 14:2985
Klesel N, Limbert M (1980) Untersuchungen zur Wirkung von einem modifizerten Immunglobulin undβ-Laktam-Antibiotika in der experimentellen Mäuse-Septikämie. Arzneim Forsch 31:1453
Kulberg AJ, Evnin DN, Tarkanova IA (1976) Enhancement of the immune response by a catabolic product of normal rabbit IgG. Immunology 30:715
Kulberg AJ, Bartova LM, Evnin DN (1978) Further studies of the adjuvant properties of homologous IgG split products. Mode of action of F(ab')2 and related fragments. Immunology 34:199
Leijh PCJ, van den Barselaar MT, Daha MR, van Furth R (1981) Participation of immunoglobulins and complement components in the intracellular killing of Staphylococcus aureus and Escherichia coli by human granulocytes. Infect Immun 33:714
Lindquist L, Jarstrand C, Lundbergh P (1978) Granulocytic function after administration of pepsin-treated human gammaglobulin. Infection 6:248
Lindquist L, Lundbergh P, Maasing R (1981) Pepsin-treated human gammaglobulin in bacterial infections. A randomized study in patients with septicemia and pneumonia. Vox Sang 40:329
Llerena JM, Ruiz-Argüelles A, Alarcon-Segovia D, Llorente L, Diaz-Jouanen E (1981) Antibody penetration into living cells. V. Interference between two Fcγ receptor mediated functions: Antibody penetration and antibody-dependent cellular cytotoxicity. Immunology 43:249
LoSpalluto J, Fehr K, Ziff M (1971) In: Barrct AJ, Dingle JT (eds) Intracellular proteases and digestion of immunoglobulins. Chapter 12, Tissue Proteinases. North-Holland Publishing Co
Mannik M, Arend WP (1971) Fate of preformed immune complexes in rabbits and rhesus monkeys. J Exp Med 134:19
Mannik M, Arend WP, Hall AP, Gilliland BC (1971) Studies on antigen-antibody complexes. I. Elimination of soluble complexes from rabbit circulation. J Exp Med 133:713
Masson PL (1976) Circulating Antigen-Antibody Complexes. La Ricerca 6 [Suppl]:69
Mayersbach H (1957) Studien an der Leber der Maus nach parenteraler Eiweißzufuhr. Z Zellforsch 45:483
Menninger H, Fehr K, Böni A, Otto K (1976) Digestion of human immunoglobulin G by bovine cathepsin B1. Immunochemistry 13:633
Menzel J, Jungfer H, Gemsa D (1978) Contribution of Immunoglobulins M and G, Complement and Properdin to the Intracellular Killing of Escherichia coli by Polymorphonuclear Leukocytes. Infect Immun 19:659
Messner RP, Laxdal R, Quie PG, Williams RC (1968) Anti-γ-globulin factors and their interaction with specific opsonins. J Clin Invest 47:1109
Mitrenga D, Arnold W, Müller O, van Mayersbach H (1975) The fate of Injected Human IgG in the Mouse Liver. Uptake, Immunological Inactivation and Lysosomal Reactions. Cell Tissue Res 156:359
Morell A, Skvaril F (1980) Struktur und biologische Eigenschaften von Immunglobulinen und Gammaglobulin-Präparaten. II. Eigenschaften von Gammaglobulin-Präparaten. Schweiz Med Wochenschr 110:80
Morell A, Barandun S (1982) Substitution mit Immunglobulinen bei primärem Antikörpermangelsyndrom. Beitr: Infusionstherapie Klin Ernähr, Vol 9, pp 16–24, Karger, Basel
Morgan EL, Tempelis CH (1978) The requirement for the Fc portion of antibody in antigen-antibody complex-mediated suppression. J Immunol 120:1669
Moriyama H, Manabe R (1979) Pepsin-treated gammaglobulin (Gamma-Venin). Therapy in herpetic keratouveitis. Folia Ophthalmol Jpn 30:1967
Müller-Eckhardt C, Lüscher EF (1968) Immune reactions of human blood platelets. I. A comparative study on the effect on platelets of heterologous anti-platelet antiserum, antigenantibody complexes, aggregated gammaglobulin and thrombin. Thromb Haemostas 20:155
Mycek MJ (1970) Cathepsins (Chapter 19) In: Perlman GE, Lorand L (eds) Methods in Enzymology, Vol XIX, Proteolytic Enzymes. Academic Press, New York, London, pp 285
Natvig JB (1970) Human Anti-γ-Globulin Antibodies Specific forγG Heavy Chain Subclasses. Immunology 19:125
Neu I (1980) Der therapeutsiche Wert von Immunglobulinen bei Infektionen des Zentralnervensystems. Med Klin 75:554
Oakes JE, Lausch RN (1981) Role of Fc fragments in antibodymediated recovery from ocular and subcutaneous herpes simplex virus infections. Infect Immun 33:109
Oberbarnscheidt J, Kölsch E (1978) Direct blockade of antigenreactive B lymphocytes by immune complexes. An “off” signal for precursors of IgM-producing cells provided by the linkage of antigen- and Fc-receptors. Immunology 35:151
Ochs HR, Vatner SF, Smith TW (1978) Reversal of inotropic effects of digoxin by specific antibodies and their Fab fragments in the conscious dog. J Pharmacol Exp Ther 207:64
Ohtsu A, Yamagami E, Watanabe T, Kurozumi S (1979) Immune reactions of platelets: Two different types of immune platelet agglutination and their comparative studies on the effects of Fc activities. Acta Haematol Jap 42:641
Okita K, Hayakawa K, Inoue Y, Nishino K, Satoh M (1979) A clinical study of the effectiveness of a pepsin-treated human normal immunoglobulin preparation (Gamma-Venin) in the treatment of Herpes Zoster. Acta Dermatol 74:209
Onyewotu H, Johnson PM, Johnson GD, Holborow EJ (1975) Enhanced uptake by guinca pig macrophages of radio-iodinated human aggregated immunoglobulin G in the presence of sera from rheumatoid patients with cutaneous vasculitis. Clin Exp Immunol 19:267
Osterland CK, Harboe M, Kunkel HG (1963) Anti-gammaglobulin factors in human sera revealed by enzymatic splitting of anti-RM antibodies. Vox Sang 8:133
Perrin LH, Joseph BS, Cooper NR, Oldstone MBA (1976) Mechanism of injury of virus-infected cells by antiviral antibody and complement: Participation of IgG, F(ab')2 and the alternative complement pathway. J Exp Med 143:1027
Prince HE, Folds JD, Spitznagel JK (1979a) In vitro production of a biologically active F(ab')2-like fragment by digestion of human IgM rheumatoid factor with human polymorphonuclear leukocyte elastasc. Mol Immunol 16:975
Prince HE, Folds JD, Spitznagel JK (1979b) Proteolysis of human IgG by human polymorphonuclear leukocyte elastase produces an Fc fragment with in vitro biological activity. Clin Exp Immunol 37:162
Probst M, Fabian W (1979) Zum Einsatz von Immunglobulinen als Frühtherapie nach Rektumexstirpation. Münch Med Wochenschr 121:1227
Ronneberger H, Vollerthun R, Zwisler O (1978) Intrazelluläre Verteilung von intravenös verabreichbarem homologem Immunglobulin in der Leber. Die Gelben Hefte 18:156
Ronneberger H, Zwisler O (1977) Antibakterielle Wirkung von Immunglobulinen: Schutzversuch. Die Gelben Hefte 17:17
Ryan GB (1977) Acute inflammation. Am J Pathol 86:184
Ryser D (1979) Katabolismus und Verteilung von Immunglobulin SRK wie sulfoniertem Gammaglobulin im menschlichen Organismus. Dissertation, Bern
Schmidt H (1939) Fermo-Serum: Über ein neues Reinigungsund Konzentrationsverfahren für Sera zur Verringerung der Serum-Krankheit. Behringwerke-Merkblätter, Nr 9
Schneider J, Weitzel H (1974) Immunglobuline. Prophylaxe und Therapie. Med Verlagsgesellschaft, Marburg
Schnoz M (1979) Therapie mit Immunglobulin SRK bei 12 Patienten mit primärem Antikörpermangelsyndrom. Dissertation, Bern
Schorlemmer HU, Allison AC (1976) Effects of activated complement components on enzyme sccretion by macrophages. Immunology 31:781
Schorlemmer HU, Bitter-Suermann D, Allison AC (1977) Complement activation by the alternative pathway and macrophage enzyme secretion in the pathogencsis of chronic inflammation. Immunology 32:929
Schorlemmer HU, Scdlacek HH, Seiler FR, Bitter-Suermann D, (1980) Evidence of rht participation of endogenous C3 in macrophage stimulation. Eur J Cell Biol 22:207
Schorlemmer HU, Gronski P, Hofstaetter T, Sedlacck HH, Seiler FR (1981) Aggregates of human IgG and immune complexes containing 7S-IgG or 5S-F(ab′)2 antibodies activate macrophages by different mechanisms. Immunobiology 159:108
Schultze HE, Schwick G (1962) Über neue Möglichkeiten intravenöser Gammaglobulin-Applikation. Dtsch Med Wochenschr 34:1643
Schur PJ, Becker EL (1963) Pepsin digestion of rabbit and sheep antibodies. The effect on complement fixation. J Exp Med 118:891
Sedlacek HH (1980a) Pathophysiological aspects of immune complex diseases. Part I. Interaction with plasma enzyme systems, cell membranes and the immune response. Klin Wochenschr 58:543
Sedlacek HH (1980b) Pathophysiological aspects of immune complex diseases. Part II. Phagocytosis, exocytosis and pathogenic Depositions. Klin Wochenschr 58:593
Sedlacek HH, Bengelsdorff HJ, Seiler FR (1979a) Concepts for the therapy of immune complex diseases. Behring Inst Mitt 64:78
Sedlacek HH, Lüben G, Bengelsdorff HJ, Gronski P, Schmidt KH, Seiler FR (1979b) Different biological distribution of immune complexes of varying antigen-antibody composition and lattice formation. Behring Inst Mitt 64:131
Seiler FR, Kanzy EJ, Ax W, Hofstactter T (1980) Quality criteria for intravenous immunoglobulin preparations with emphasis on Fe-mediated functions and phagocytosis. In: Alving BM, Finlayson JS (eds) Immunoglobulins: Characteristics and Uses of Intravenous Preparations. DHEW Publication No. (FDA)-80-9005, Washington DC, US Government Printing Office, pp 207
Shavit ZB, Raz A, Goldman R (1979) Complement and Fereceptor-mediated phagocytosis of normal and stimulated mouse peritoneal macrophages. Eur J Immunol 9:385
Sissons JGP, Cooper NR, Oldstone MBA (1979) Alternative complement pathway-mediated lysis of measles virus infected cells: Induction by IgG antibody bound to individual viral glycoproteins and comparative efficacy of F (ab′)2 and Fab fragments. J Immunol 123:2144
van Snick JL, Masson PL (1978) The effect of complement on the ingestion of soluble antigen-antibody complexes and IgM aggregates by mouse peritoneal macrophages. J Exp Med 148:903
van Snick JL, van Roost E, Markowetz B, Cambiaso CL, Masson PL (1978) Enhancement by IgM rheumatoid factor of in vitro ingestion by macrophages and in vivo clearance of aggregated IgG or antigen antibody complexes. Eur J Immunol 8:279
Spiegelberg HL, Götze O (1972) Conversion of C3 proactivator and activation of the alternate pathway of complement activation by different classes and subclasses of human immunoglobulins. Fed Proc 31:655
Steele EJ, Reynolds BL, Rother U, Rowley D (1977) The mechanism of complement fixation by rabbit F (ab′)2: Bacteriacidal activity of chelated serum and C4-deficient serum. Immunochemistry 14:681
Steele EJ, Rowley D (1977) The mechanisms of complement fixation by rabbit F(ab′)2: Properties of the bactericidal reaction. Immunochemistry 14:319
Stendahl O, Tagesson C, Magnusson KE, Edebo L (1977) Physicochemical consequences of opsonization of Salmonella typhimurium with hyperimmune IgG and complement. Immunology 32:11
Stephan W (1980) Intravenöse Immunglobuline. Proteinchemische und immunbiologische Charakterisierung der verschiedenen Präparatetypen. Arzneim Forsch 30:116
Stokes J (1951) Usefulness of immune serum globulin in viral hepatitis. N Engl J Med 285:967
Takahashi M, Takahashi S, Hirose S (1980) Solubilization of Antigen-Antibody Complexes: A New Function of Complement as a Regulator of Immune Reactions. Prog Allergy 27:134
Taliaferro WH, Talmage DW (1956) Antibodies in the rabbit with different rates of metabolic decay. J Infect Dis 99:21
Theofilopoulos AN, Dixon FJ (1980) Immune Complexes in Human Diseases. A review. Am J Pathol 100:531
Trautmann M, Brückner O, Hofstaetter T, Seiler FR, Hahn H (1982) Schutzwirkung verschiedener Antikörperpräparationen bei einer experimentellen bakteriellen Scpsis. Beitr: Infusionstherapie Klin Ernähr, Vol 9, pp 155–165. Karger, Basel
Tympner KD, Klose PK, Janka G, Liegel D (1976) Einfluß intravenös-verträglicher Immunglobuline auf die Phagozytose-Leistung der Granulozyten in vitro. Münch Med Wochenschr 120:251
Uhr JW, Baumann JB (1961) Antibody Formation. I. The Suppression of Antibody Formation by Passively Administered Antibody. J Exp Med 113:935
Urbaschek B (1975) Zur pathophysiologischen Bedeutung der Endotoxine. Fortschr Med 93:22
Urbaschek B (1976) Zur Frage der pathogenetischen Bedeutung von Endotoxinen bei Infektionen mit gramnegativen Bakterien. Zentralbl Bakteriol Mikrobiol Hyg [B] 235:26
Vollerthun R, Möller W (1980) Uptake and Transport of Immunoglobulin in the Chick Coroid Plexus. I. Studies with Enzyme-treated Human Immunoglobulin in Tissue Culture. Cell Tissue Res 213:393
Vollerthun R, Sedlacek HH, Ronneberger H (1977) Gewebeverteilung von nativem und enzymbehandeltem Human-Immunglobulin. Experimentelle Untersuchungen. Dtsch Med Wochenschr 102:684
Waldmann TA, Strober W (1969) Metabolism of immunoglobulin. Prog Allergy 13:1
Weil AJ, Parfentjev JV, Bowmann KL (1938) Antigenic Qualities of Antitoxins. J Immunol 35:399
Weißbarth E, Sedlacek HH, Seiler FR, Fricke M, Deicher H (1979) Release of3H-serotonin and endogenous β-thromboglobulin from human platelets by immune complexes. Behring Inst Mitt 64:121
Zwisler O, Joachim I (1978) Ampicillin-resistente Mutanten von Staph. aureus durch Gammaglobulin reduziert. Diagnostik Intensivther 2:11
Zwisler O, Ronneberger H (1978) Steigerung der Wirkung von Ampicillin durch intravenös applizierbares 5S-Immunglobulin. Verh Dtsch Ges Inn Med 84:1509
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Sedlacek, H.H., Gronski, P., Hofstaetter, T. et al. The biological properties of immunoglobulin G and its split products [F(ab')2 and Fab]. Klin Wochenschr 61, 723–736 (1983). https://doi.org/10.1007/BF01497399
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DOI: https://doi.org/10.1007/BF01497399