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A practicable method for the analysis of T lymphocyte subsets in CSF lymphopleocytosis

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Summary

A practicable indirect immunofluorescence technique for the analysis of surface markers of cerebrospinal fluid (CSF) cells is described. Preliminary results in 10 patients with acute or chronic CSF lymphoplcocytosis of different etiology showed an almost uniform pattern of cell subsets. The majority of CSF cells represented OKT3-positive T lymphocytes with a mean helper (OKT4-positive) to suppressor (OKT8-positive) ratio of 3,4 to 1.

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References

  • Cashman N, Martin C, Eizenbaum J-F, Degos J-D, Bach MA (1982) Monoclonal antibody — defined cells in multiple sclerosis cerebrospinal fluid. J Clin Invest 70:387–392

    PubMed  Google Scholar 

  • Editorial (1980) Identifying T cells in man. Lancet 2:781–782

  • Kam-Hansen S, Fryden A, Link H (1978) B- and T-lymphocytes in cerebrospinal fluid and blood in multiple sclerosis, optic neuritis, and mumps meningitis. Acta Neurol Scand 58:93–103

    Google Scholar 

  • Manconi PE, Zaccheo D, Bugiani O, Fadda MF, Griffoni V, Mantovani G, Del Giacco GS, Tognella S (1976) T-and B-lymphocytes in normal cerebrospinal fluid. N Engl J Med 294:49

    Google Scholar 

  • Naess A (1976) Demonstration of T-lymphocytes in cerebrospinal fluid. Scand J Immunol 5:165–168

    PubMed  Google Scholar 

  • Panitch HS, Francis GS (1982) T-lymphocyte subsets in cerebrospinal fluid in multiple sclerosis. N Engl J Med 307:560–561

    Google Scholar 

  • Reinherz EL, Kung PC, Goldstein G, Levey RH, Schlossman SF (1980) Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T cell lineage. Proc Natl Acad Sci USA 77:1588–1592

    PubMed  Google Scholar 

  • Reinherz EI, Schlossman SF (1980) Current concepts in immunology: regulation of the immune response — inducer and suppressor T-lymphocyte subsets in human beings. N Engl J Med 303:370–373

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Neurologische Univ.-Klinik, Moorenstr. 5, D-4000, Düsseldorf 1, Germany

    R. Hohlfeld, A. Schwartz, U. Brocke & K. V. Toyka

Authors
  1. R. Hohlfeld
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  2. A. Schwartz
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  3. U. Brocke
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  4. K. V. Toyka
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Supported by the Deutsche Forschungsgemeinschaft (To 63/2–4, SFB 200, B5)

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Hohlfeld, R., Schwartz, A., Brocke, U. et al. A practicable method for the analysis of T lymphocyte subsets in CSF lymphopleocytosis. Klin Wochenschr 61, 933–934 (1983). https://doi.org/10.1007/BF01537535

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  • DOI: https://doi.org/10.1007/BF01537535

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