Summary
Fibronectin is a glycoprotein belonging to the opsonic system and able to mediate phagocytosis by the reticuloendothelial system (RES). Severe intoxications are often followed by a diminished capacity of RES-clearance. Patients with severe drug intoxications have lower concentrations of fibronectin in plasma than healthy persons. Charcoal hemoperfusion lowers plasma fibronectin by an average of 4.7 mg/dl. Initial values below 15 mg/dl did not undergo a significant decrease in the case of hemoperfusion. Regarding these findings, determination of plasma fibronectin seems a useful parameter for monitoring RES function during treatment of drug-intoxicated patients by hemoperfusion.
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Herrn Prof. Dr. med. W.H. Hauss zum 75. Geburtstag gewidmet
A part of this publication had been reported on the 10th Int. Congr. of the Eur. Assoc. of Poison Control Centers, Brighton, 3–6 Aug., 1982
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Lohmann, J., Pott, G., Voss, B. et al. Drug intoxication: Influence of hemoperfusion on human plasma fibronectin. Klin Wochenschr 61, 369–372 (1983). https://doi.org/10.1007/BF01485029
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DOI: https://doi.org/10.1007/BF01485029