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Vindesine/Cisplatin chemotherapy in relapsed or primarily resistant small-cell carcinoma of the lung

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Summary

Thirty-eight pretreated patients with primarily resistant [6] or relapsed [32] small-cell lung cancer were treated with a combination of vindesine (3–4 mg/m2) and cisplatin (60–100 mg/m2). Eight patients responded to this therapy with three (8%) complete and five (13%) partial remissions. Minor responses were noted in 12 (32%) additional patients. Chemotherapeutic response was rare in regions of prior irradiation. In the complete remission group survival from start of vindesine/cisplatin therapy lasted 61, 48 and 38 weeks, respectively. In the “less-than-complete-remission” group median survival was 12 weeks. Nausea and vomiting were the prominent side-effects, while only mild to moderate myelosuppression was noticed in most cases. The vindesine/cisplatin combination showed significant activity in heavily pretreated small-cell lung carcinoma. However, the remission rates remain low in this unfavourable condition, which might be due to pronounced chemotherapeutic resistance in previously irradiated areas.

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Authors and Affiliations

  1. Innere Universitätsklinik und Poliklinik (Tumorforschung), Westdeutsches Tumorzentrum Essen, Germany

    N. Niederle, J. Schütte, W. Krischke, S. Seeber & C. G. Schmidt

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  1. N. Niederle
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  2. J. Schütte
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  3. W. Krischke
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  4. S. Seeber
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  5. C. G. Schmidt
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Supported by BMFT, Bonn: „Arzneimittelentwicklung undtestung für die Krebstherapie“

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Niederle, N., Schütte, J., Krischke, W. et al. Vindesine/Cisplatin chemotherapy in relapsed or primarily resistant small-cell carcinoma of the lung. Klin Wochenschr 62, 783–786 (1984). https://doi.org/10.1007/BF01721778

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  • DOI: https://doi.org/10.1007/BF01721778

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