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Changes in intravascular fluid composition following blood replacement with perfluorocarbon emulsion in the rat

  • Symposien Care Of The Post-Operative Surgical Patient Symposium Held On September 8–9, 1983 In Edinburgh
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Summary

The effects of near total blood replacement with the proprietary perfluorocarbon emulsion, Fluosol-DA, have been examined in conscious, chronically catheterized rats. Animals survived for up to 48 h with a haematocrit of <2%. No overt changes in cardiovascular or respiratory functions occurred during blood replacement but thereafter, animals showed a progressive deterioration of haemodynamic control. Changes in intravascular fluid composition during and following exchange-transfusion have been monitored and the extent to which these changes could have contributed to the eventual disruption of homeostasis is discussed.

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Abbreviations

PFC:

perfluorocarbons

RES:

reticuloendothelial system

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Authors and Affiliations

  1. Department of Zoology, University of Nottingham, University Park, Nottingham, UK

    K. C. Lowe

  2. Department of Surgery, Addenbrooke's Hospital, Cambridge, UK

    Denise C. McNaughton

  3. Formerly of the Physiological Laboratory, University of Cambridge, Cambridge, UK

    The Late R. N. Hardy

Authors
  1. K. C. Lowe
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  2. Denise C. McNaughton
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  3. The Late R. N. Hardy
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Lowe, K.C., McNaughton, D.C. & Hardy, T.L.R.N. Changes in intravascular fluid composition following blood replacement with perfluorocarbon emulsion in the rat. Klin Wochenschr 63, 1028–1034 (1985). https://doi.org/10.1007/BF01737640

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  • DOI: https://doi.org/10.1007/BF01737640

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