Summary
Oral contraception as well as cigarette smoking influence haemostasis. The simulataneous effect of both on blood coagulation and fibrinolysis was studied in nine female smokers. While continuing oral contraception after a 4-week abstinence from smoking the concentration of fibrinogen, antithrombin III and alpha1-Antitrypsin decreased (P<0.01 orP<0.04) and of plasminogen increased (P<0.03). The other coagulation parameters remained unchanged. Although all determinations of these parameters were in the normal range, the observed trends were statistically significant. The concentrations of the fibrinopeptide A and B 15–42 did not differ. It is concluded that the observed alteration is caused by cessation from cigarette smoking.
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This work has been supported by grants from Forschungsrat Rauchen und Gesundheit
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Harenberg, J., Staiger, C., de Vries, J.X. et al. The effects of a combination of cigarette smoking and oral contraception on coagulation and fibrinolysis in human females. Klin Wochenschr 63, 221–224 (1985). https://doi.org/10.1007/BF01731173
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DOI: https://doi.org/10.1007/BF01731173