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Vergleich der Wirkung von Linolensäure und Eicosapentaensäure auf die Prostaglandinbiosynthese und Thrombozytenfunktion beim Menschen

Effects of linolenic and eicosapentaenoic acids on prostaglandin biosynthesis and platelet function in man

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Summary

Platelet aggregation, bleeding time, prostaglandin biosynthesis and plasma cholesterol fatty acids were investigated in 12 healthy females (25–32 years), who were given different amounts of linolenic acid (0%, 4%, 8%, 12%, 16% of total energy intake) or eicosapentaenoic acid (1.7%) with formula diets for 2 weeks each. Linolenic and eicosapentaenoic acids prolonged the bleeding time and inhibited platelet aggregation and prostaglandin biosynthesis. These effects became apparent after a linolenic acid intake of 12% of the energy intake. A decrease in PGE in 24 h urine was observed after intake of linolenic acid amounting to 8% of energy intake. Eicosapentaenoic acid influenced all parameters measured ten times more than linolenic acid. Linolenic acid intake had no effect on the ratio of linoleic/arachidonic acids in plasma cholesterol esters in contrast to in vitro findings. Thus energy intake comprising 1.7% of eicosapentaenoic acid is sufficient to affect thrombocyte function in man. The concomitant intake of linolenic-type fatty acids inhibits the biosynthesis of prostaglandins E2 and F2α to different degrees.

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Abbreviations

Arachidonsäure:

all-cis 5.8.11.14 Eicosatetraensäure (20:4, n-6)

Docosahexaensäure:

all-cis 4.7.10.13.16.19 Docosahexaensäure (22:6, n-3)

EPA, Eicosapentaensäure:

all-cis 5.8.11.14.17 Eicosapentaensäure (20:5, n-3)

Linolensäure:

all-cis 9.12.15 Octadecatriensäure (18:3, n-3)

Linolsäure:

all-cis 9.12 Octadecadiensäure (18:2, n-6)

PGE, F:

Prostaglandin E,F

FD:

Formeldiät

FDL:

Formeldiät mit Linolensäure

FDE:

Formeldiät mit Eicosapentaensäure

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Authors and Affiliations

  1. Medizinische Poliklinik der Universität München, Germany

    O. Adam, G. Wolfram & N. Zöllner

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  1. O. Adam
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  2. G. Wolfram
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  3. N. Zöllner
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Gefördert durch eine Sachbeihilfe von der Deutschen Forschungsgemeinschaft

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Adam, O., Wolfram, G. & Zöllner, N. Vergleich der Wirkung von Linolensäure und Eicosapentaensäure auf die Prostaglandinbiosynthese und Thrombozytenfunktion beim Menschen. Klin Wochenschr 64, 274–280 (1986). https://doi.org/10.1007/BF01711937

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  • DOI: https://doi.org/10.1007/BF01711937

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