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Untersuchungen zur Erfassung der Nephrotoxizität von humanem Alpha-2b-Interferon unter besonderer Berücksichtigung der Analyse von Harnenzymen bei Patienten mit chronischer myeloischer Leukämie

Analysis of urinary enzyme excretion as a parameter of the nephrotoxicity of human interferon alpha-2b in patients with chronic myelogenous leukemia

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Summary

The nephrotoxic potential of alpha-interferon (IFN alpha-2b) was analysed in 21 patients with chronic myeloid leukemia. As particularly sensitive parameters in the detection of subclinical renal injury we measured the excretion of the following urinary enzymes: lactate dehydrogenase (LDH), gamma-glutamyltransferase (GGT), leucine arylaminidase (LAP), β-galactosidase (GAL) and N-acetyl-beta-glucosaminidase (NAG). Additionally, protein excretion and urinary sediment were analysed. In 18 of 21 patients a significant increase in the excretion of LDH, LAP, GGT and NAG was found, in 6 patients there was an additional rise in the output of GAL. Eleven patients developed proteinuria up to 2 g/l, one patient excreted up to 9 g/l. Enzymuria and protein excretion decreased in all patients after reduction of the IFN alpha-2b dosage and disappeared in two patients following cessation of therapy. The high incidence of nephrotoxic events in patients with CML during IFN alpha-2b therapy might be mostly due to immunological or substance-specific effects.

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Abbreviations

CML:

chronische myeloische Leukämie

GAL:

Beta-Galactosidase

GGT:

Gamma-Glutamyltransferase

IFN alpha-2b:

Interferon alpha-2b

LAP:

Leucinarylamidase

LDH:

Laktatdehydrogenase

NAG:

N-Acetylbeta-Glucosaminidase

SD:

Standardabweichung

\(\bar X\) :

Mittelwert

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Authors and Affiliations

  1. Innere Klinik und Poliklinik (Tumorforschung), Westdeutsches Tumorzentrum, Germany

    E. Kurschel & N. Niederle

  2. Abt. für Nieren- und Hochdruckkranke der Medizinischen Klinik und Poliklinik des Universitätsklinikums der GHS Essen, Germany

    U. Metz-Kurschel

  3. Institut für Klinische Chemie der Städtischen Krankenanstalten München-Bogenhausen, Germany

    W. Hofmann

Authors
  1. E. Kurschel
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  2. U. Metz-Kurschel
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  3. W. Hofmann
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  4. N. Niederle
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Kurschel, E., Metz-Kurschel, U., Hofmann, W. et al. Untersuchungen zur Erfassung der Nephrotoxizität von humanem Alpha-2b-Interferon unter besonderer Berücksichtigung der Analyse von Harnenzymen bei Patienten mit chronischer myeloischer Leukämie. Klin Wochenschr 65, 667–672 (1987). https://doi.org/10.1007/BF01875502

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  • DOI: https://doi.org/10.1007/BF01875502

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