Summary
In a 61-year-old woman recurrent bacterial infections were caused by immune neutropenia which was resistant to high-dose cortisone and plasmapheresis. However, high-dose intravenous 7S-immunoglobulin therapy (30 g for 6 days) induced a long-term remission for 35 months. This treatment modality is safe and should be used as a first-line agent.
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Abbreviations
- CFU-c:
-
Colony-forming units
- DNA:
-
Desoxyribonucleic acid
- RIA:
-
Radioimmunoassay
- RNA:
-
Ribonucleic acid
References
Fateh-Moghadam A, Besinger U, Geursen RG (1982) Ein klinisches Modell zur Regulation der humoralen Immunantwort. Beitr Infusionsther Klin Ernähr 9:69–79
Fehr J, Hofmann V, Kappeler U (1982) Transient reversal of thrombocytopenia in idiopathic thrombocytopenic purpura by high-dose intravenous gamma globulin. N Engl J Med 306:1254–1258
Gross B, Haessig A, Luescher EF, Nydegger VE (1983) Monomeric IgG preparations for intravenous use inhibit platelet stimulation by polymeric IgG. Br J Haematol 53:289–299
Henke M, Engler H, Engelhardt R, Löhr GW (1986) Successful therapy of sarcoidosis-associated thrombocytopenia refractory to corticosteroids by a single course of human gammaglobulins. Klin Wochenschr 64:1209–1211
Imbach P, Jungi TW (1983) Possible mechanisms of intravenous immunoglobulin treatment in childhood idiopathic thrombocytopenic purpura (ITP). Blut 46:117–124
Imbach P, Barandum S, D'Apuzzo V, Baumgartner G, Hirt A, Morell A, Rossi E, Schoni M, Vest M, Wagner HD (1981) High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet I:1128–1131
Masson PL (1979) The therapeutic use of human immunoglobulin selected on the basis of antibody activity against circulating antigens. In: Peters H, Bright B (eds) Plasmaprotein Pathology, Oxford
McIntosh S, Johnson C, Hartigan P, Baumgarten A, Dwyer JM (1981) Immunoregulatory abnormalities in children with thrombocytopenic purpura. J Pediatr 99:525–530
Minchinton RM, Waters AH, Kendra J, Barrett AJ (1982) Autoimmune thrombocytopenia acquired from an allogeneic bone marrow graft. Lancet II:627–629
Pike BL, Robinson WA (1970) Human bone marrow colony growth in agar-gel. J Cell Physiol 76:77–81
Pollack S, Cunningham-Rundles C, Smithwick EM, Baradun S, Good RA (1982) High-dose intravenous gamma globulin for autoimmune neutropenia. N Engl J Med 307:253
Salama A, Müller-Eckhardt C, Kiefel V (1983) Effect of intravenous immunoglobulin in immune thrombocytopenia. Lancet I:193–195
Schmidt RE, Budde U, Schäfer G, Stroehmann J (1981) High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura. Lancet II:475
Uchino H, Yasunaga K, Akatsuka J (1984) A cooperative clinical trial of high dose immunoglobulin therapy in 177 cases of idiopathic thrombocytopenic purpura. Thromb Haemost 51:182–185
Wiesneth M, Pflieger H, Frickhofen N, Heimpel H (1985) Idiopathic combined immunocytopenia. Br J Haematol 61:339–348
Zubler RH, Lange GL, Lambert PH, Miescher PA (1976) Detection of immune complexes in unheated sera by a modified125I-C1q binding test. J Immunol 116:232–235
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Mann, K., Fateh-Moghadam, A., Pfeiffer, A. et al. Long-term remission of immune neutropenia after treatment with high-dose intravenous 7S-immunoglobulin. Klin Wochenschr 65, 985–988 (1987). https://doi.org/10.1007/BF01717834
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DOI: https://doi.org/10.1007/BF01717834