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Alterations of acyl-neuraminic acids on T-lymphocytes in cases of melanoma

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Summary

Content and distribution of the different sialic acids on human lymphocytes, isolated from 7–10 ml of fresh human blood, were determined using microanalytical methods, such as HPLC and a colorimetric test. Comparison of the data of patients with melanoma with those of healthy persons shows an evident increase of the sialic acid content combined with a shift of the sialic acid distribution to higher O-acetylated derivatives.

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Abbreviations

HPLC:

High performance liquid chromatography

Neu5Ac:

N-acetylneuraminic acid

Neu5.9Ac2 :

N-acetyl-9,0-acetylneuraminic acid

Neu5Ac2.3en:

N-acetyl-2.3-didehydroneuraminic acid

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Authors and Affiliations

  1. Biochemie, Universität des Saarlandes, Germany

    R. Holzhauser, H. Faillard & W. Klose

  2. Abteilung für Impfwesen, TU München, Institut für Toxikologie und Umwelthygiene, Germany

    W. Huber & H. Stickl

  3. Dermatologische Klinik, Ludwig-Maximilians-Universität München, Germany

    M. Landthaler

Authors
  1. R. Holzhauser
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  2. H. Faillard
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  3. W. Klose
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  4. W. Huber
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  5. H. Stickl
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  6. M. Landthaler
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Additional information

Part of this work was presented at the IXth International Symposium on Glycoconjugates, Lille, France (1987)

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Holzhauser, R., Faillard, H., Klose, W. et al. Alterations of acyl-neuraminic acids on T-lymphocytes in cases of melanoma. Klin Wochenschr 66, 540–544 (1988). https://doi.org/10.1007/BF01736523

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  • DOI: https://doi.org/10.1007/BF01736523

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