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Der akute Myokardinfarkt: Myosinleichtkettenfreisetzung und Ventrikelfunktion

The acute myocardial infarction: Release of cardiac myosin light chains and left ventricular function

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Summary

Infarct size can be estimated noninvasively by analysis of circulating CK-MB and/or cardiac myosin light chains. To investigate whether myosin light chains release is correlated with the impairment of left ventricular function in acute myocardial infarction, this marker protein was determined by liquid phase radioimmunoassay in serial blood samples of 25 patients. Likewise CK-MB was measured in the same blood samples. From the serum concentration changes the cumulative appearance was calculated as an estimate of infarct size. Left ventricular enddiastolic pressure, global and regional ejection fraction were measured immediately and 3 weeks after admission. Particularily during the chronic phase of myocardial infarction a close correlation was found between serological estimates of infarct size and impairment of left ventricular function. The cumulative appearance of myosin light chains was superior to CKMB in assessing the hemodynamic impact of myocardial infarction in the acute and chronic stage. Therefore, myosin light chains are an appropriate serological indicator for the hemodynamic significance of myocardial infarction during the acute and chronic stage and might allow an assessment of the patients' risk.

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Abbreviations

AMI:

akuter Myokardinfarkt

CK:

Kreatinkinase

CK-MB:

MB-Isoenzym der Kreatinkinase

EDP:

enddiastolischer Druck

EF glob:

Austreibungsfraktion

EF region:

gemittelte Halbachsenverkürzung im Infarktareal

IS:

Infarktgröße

LDH:

Lactatdehydrogenase

LV:

linksventrikulär

SM:

Serummaximalwert

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Authors and Affiliations

  1. Abteilung Innere Medizin III der Universität Heidelberg, Germany

    H. A. Katus, K. W. Diederich, H. C. Mehmel, Th. Scheffold, F. Schwarz & W. Kübler

Authors
  1. H. A. Katus
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  2. K. W. Diederich
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  3. H. C. Mehmel
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  4. Th. Scheffold
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  5. F. Schwarz
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  6. W. Kübler
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Unterstützt durch die Deutsche Forschungsgemeinschaft (Ka 423/2-2)

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Katus, H.A., Diederich, K.W., Mehmel, H.C. et al. Der akute Myokardinfarkt: Myosinleichtkettenfreisetzung und Ventrikelfunktion. Klin Wochenschr 66, 784–789 (1988). https://doi.org/10.1007/BF01726579

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  • DOI: https://doi.org/10.1007/BF01726579

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