Skip to main content
Log in

Intraoperative localization of malignant pheochromocytoma by 123-i-metaiodobenzylguanidine single probe measurement

  • Originalien
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

Metaiodobenzylguanidine (MIBG) imaging is a well-established method for locating intra-and extraadrenal pheochromocytomas. We investigated whether preoperative injection of 123-I-MIBG might be useful for intraoperative staging of chromaffine tumor cells. This was performed in a 46-year-old patient in whom the diagnosis of a malignant pheochromocytoma had been established by 123-I-MIBG imaging and enhanced catecholamine secretion. The rationale for intraoperative staging in this patient was a discrepancy between computed tomography (CI) of the abdomen and the radionuclide imaging, because scintigraphy revealed a mass with MIBG uptake in the right lower abdomen that could not be visualized by CT. We thus applied a preoperative dose of 4 mCi 123-I-MIBG and determined tissue activity by direct organ measurement. A right abdominal mass was thus identified with an activity of 10×104 impulses/s as compared to normal tissue (15×102). The left-sided tumor was found to be identified correctly by prior CT and MIBG imaging. We thus conclude that intraoperative application of this single probe measurement might help to identify chromaffine tumor cells that have not been located fully by CT.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

Ci:

curie

CT:

computed tomography

MIBG:

metaiodobenzylguanidine

References

  1. Bravo RL, Gifford RW (1984) Current concepts: pheochromocytoma diagnosis, location and management. N Engl J Med 311:1298–1303

    Google Scholar 

  2. Bravo EL, Tarazi RC, Fouad FM, Vidt DG, Gifford RW (1981) Clonidine suppression test — a useful aid in the diagnosis of pheochromocytoma. N Engl J Med 305:623–626

    Google Scholar 

  3. Chatal JF, Charbonnel B (1985) Comparison of iodobenzylguanidine imaging with computed tomography in localizing pheochromocytoma. J Clin Endocrinol Metab 61:769–772

    Google Scholar 

  4. Editorial (1984) Iodobenzylguanidine for localization and treatment of pheochromocytoma. Lancet II:905–907

    Google Scholar 

  5. Fischer M, Vetter W, Winterberg B, Hengstmann J, Zidek W, Friemann J, Vetter H (1984) Scintigraphic localization of pheochromocytomas. Clin Endocrinol 20:1–7

    Google Scholar 

  6. Keßel F, Hahn K, Eißner D, Beyer J, Thelen M (1986) 131-Jod-Meta-Jodobenzylguanidin-Szintigraphie und -therapie bei malignem Phäochromozytom. Internist 27:70–73

    Google Scholar 

  7. Lehnert H, Walger P (1985) Plasma 3-methoxy-4-hydroxyphenethylenglycol in pheochromocytoma. Cardiology [Suppl 1] 72:160–162

    Google Scholar 

  8. Nakajo M, Shapiro B, Lopp J, Kalff V, Gross MD, Sisson JC, Beierwaltes WH (1983) The normal and abnormal distribution of the adrenomedullary imaging agent 131-I-MIBG in man: evaluation by scintigraphy. J Nucl Med 24:672–676

    Google Scholar 

  9. Sisson JC, Shapiro B, Beierwaltes WH, Glowniak JV, Nakajo M, Mangner TJ, Carey JE, Swanson DP, Copp JE, Satterlee WG, Wieland DM (1984) Radiopharmaceutical treatment of malignant pheochromocytoma. J Nucl Med 25:197–206

    Google Scholar 

  10. Stewart BH, Bravo EL, Haaga J, Meaney TF, Tarazi R (1978) Localization of pheochromocytoma by computed tomography. N Engl J Med 299:460–461

    Google Scholar 

  11. Taylor HC, Mayes D, Anton AH (1986) Clonidine suppression test for pheochromocytoma: examples of misleading results. J Clin Endocrinol Metab 63:238–242

    Google Scholar 

  12. Wieland DM, Wu JL, Brown LE, Mangner TJ, Swanson DP, Beierwaltes WH (1980) Radiolabelled adrenergic neuroblocking agents: adrenomedullary imaging with iodobenzylguanidine. J Nucl Med 21:349–353

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lehnert, H., Weber, P., Nägele-Wöhrle, B. et al. Intraoperative localization of malignant pheochromocytoma by 123-i-metaiodobenzylguanidine single probe measurement. Klin Wochenschr 66, 61–64 (1988). https://doi.org/10.1007/BF01713012

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01713012

Key words

Navigation