Summary
We report three patients with advanced breast cancer who received hyperthermia (43°C over 1 h, weekly ×4) and radiotherapy as palliative treatment for chest-wall recurrence. The case reports demonstrate situations where hyperthermia may be beneficial. These include tumours where radiotherapy alone is not expected to achieve control, such as large fungating tumours, and in previously irradiated areas. In these patients, hyperthermia with radiation achieves better local control of the tumour and delays the need for systemic chemotherapy. This may improve the quality of palliation.
Similar content being viewed by others
References
Arriagada R, Mouriesse BS, Sarrazin D, Clark RM, Deboer G (1985) Radiotherapy alone in breast cancer. I. Analysis of tumor parameters, tumor dose and local control: the experience of the Gustave-Roussy Institute and the Princess Margret Hospital. Int J Radiat Oncol Biol Phys 11:1751–1757
Bhuyan BK (1979) Kinetics of cell kill by hyperthermia. Cancer Res 39:2277–2284
Dahl O (1988) Interaction of hyperthermia and chemotherapy. Recent Results Cancer Res 107:157–169
Dahl O, Mella O, Mehus A, Liavaag PG (1987) Clinical hyperthermia combined with drugs and radiation. A phase I/II study. Strahlenther Onkol 163:446–448
Engelhardt R (1987) Hyperthermia and drugs. Recent Results Cancer Res 104:136–184
Field SB, Anderson RL (1982) Thermotolerance: a review of observations and possible mechanisms. Natl Cancer Inst Monogr 61:193–201
Field SB, Franconi C (1987) Physics and technology of hyperthermia. Martinus-Nijhoff, Dordrecht Boston Lancaster
Gonzalez Gonzalez D, van Dijk JDP, Blank LECM (1988) Chestwall recurrences of breast cancer: results of combined treatment with radiation and hyperthermia. Radiother Oncol 12:95–103
Hahn GM (1982) Hyperthermia and cancer. Plenum Press, New York
Hahn GM (1984) Hyperthermia for the engineer: a short biological primer. IEEE Trans Biomed Eng 31:3–8
Henderson C, Canellos GP (1980) Cancer of the breast. N Engl J Med 302:17–30
Kapp DS (1986) Site and disease selection for hyperthermia clinical trials. Int J Hyperthermia 2:139–156
Lindholm CE, Kjellen E, Nilsson P, Hertzman S (1987) Microwave-induced hyperthermia and radiotherapy in human superficial tumours: clinical results with a comparative study of combined treatment versus radiotherapy alone. Int J Hyperthermia 3:393–411
Mella O, Dahl O, Mehus A (1987) Problems in practical clinical hyperthermia: initial experience with the BSD-1000 system for local hyperthermia. Strahlenther Onkol 163:436–438
Overgaard J, Nielsen OS (1983) The importance of thermotolerance for clinical treatment with hypertermia. Radiother Oncol 1:167–178
Streffer C, van Beuningen D (1987) The biological basis for tumour therapy by hyperthermia and radiation. In: Streffer C, (ed) Hyperthermia and the therapy of malignant tumors. Recent Results Cancer Res 104:24–52
Wiedemann G, Schem BC, Dahl O, Mella O, Wagner T (1988) Hyperthermie. Grundlagen und Stellenwert einer neuen Therapiemodalität in der Onkologie. Dtsch Med Wochenschr 113:787–790
Zee van der J, Rhoon van GC, Wike-Hooley JL (1985) Clinically derived dose effect relationship for hyperthermia given in combination with low dose radiotherapy. Br J Radiol 58:243–250
Author information
Authors and Affiliations
Additional information
Supported by the Norwegian Cancer Society and (R.S.C.) by the S. Wales Cancer Research Campaign
Rights and permissions
About this article
Cite this article
Wiedemann, G., Mella, O., Coltart, R.S. et al. Hyperthermia improves local tumour control in locally advanced breast cancer. Klin Wochenschr 66, 1034–1038 (1988). https://doi.org/10.1007/BF01733451
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01733451