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Acute and long-term effects of low-density lipoprotein apheresis on the serum concentrations of vitamins E and A

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Summary

Serum α-tocopherol and retinol concentrations were followed in four heterozygous adults and one homozygous child with familial hypercholesterolemia being treated by regular low-density lipoprotein (LDL) apheresis. Approximately 50% of plasma α-tocopherol was eliminated during a single apheresis procedure in the heterozygous adults, while a complete elimination of this vitamin along with LDLs was observed in the homozygous child. Absolute losses of α-tocopherol amounted to 13.4–22.5 mg/apheresis and are equivalent to the recommended dietary intake for 1.5 to 2 days. Despite these losses, no changes were observed either in serum α-tocopherol levels or in the ratio of α-tocopherol/total serum lipids after 12 months regular apheresis treatment. Serum retinol concentrations only showed a small decrease on apheresis, there being apparently no specific elimination of this vitamin. The absolute losses ranged from 42–422 µg/apheresis and were, therefore, much lower than the recommended dietary intake of the equivalent of 1500 µg retinol/day. It is concluded that no extra supplementation of these vitamins is required during LDL-apheresis therapy, although it may be advisable to monitor vitamin E status in patients on long-term, intensive therapy.

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Authors and Affiliations

  1. Abteilung für Klinische Chemie, Zentrum Innere Medizin, Universitätsklinikum, Göttingen

    V. W. Armstrong, D. Niedmann, H. Wagner, P. Schuff-Werner & D. Seidel

  2. Abteilung Nephrologie Zentrum Innere Medizin, Universitätsklinikum, Göttingen

    T. Eisenhauer & G. Janning

Authors
  1. V. W. Armstrong
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  2. D. Niedmann
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  3. T. Eisenhauer
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  4. G. Janning
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  5. H. Wagner
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  6. P. Schuff-Werner
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  7. D. Seidel
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Dedicated to Professor Dr. N. Zöllner on the occassion of his 65th birthday

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Armstrong, V.W., Niedmann, D., Eisenhauer, T. et al. Acute and long-term effects of low-density lipoprotein apheresis on the serum concentrations of vitamins E and A. Klin Wochenschr 66, 123–128 (1988). https://doi.org/10.1007/BF01774226

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  • DOI: https://doi.org/10.1007/BF01774226

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