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Hämorheologie und Akute Phase Reaktion nach Thrombendarteriektomie der extracraniellen Arteria carotis

Hemorheology and acute phase reaction following thrombendarterectomy of the carotid artery

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Summary

In 39 patients with hemodynamically significant stenoses of the internal carotid artery thrombendarterectomy was performed. Hemorheological properties and plasma protein levels were studied pre- and postoperatively over a period of 14 days. In comparison to age-matched healthy controls preoperative plasma viscosity, red cell aggregation, fibrinogen, haptoglobin and alpha-1-antitrypsin were significantly elevated. After surgical trauma there was an increase in fibrinogen, alpha-1-antitrypsin, haptoglobin and ceruloplasmin, whereas alpha-2-macroglobulin, immunglobulin A and immunglobulin G decreased significantly. Plasma viscosity, red cell aggregation, red cell filterability, fibronectin and immunglobulin M remained unchanged. We conclude that our patients showed a non specific chronic “hematological stress syndrome” with raised acute phase reactants and corresponding hemorheological changes preoperatively; despite postoperative acute phase reaction no further deterioration of the rheological parameters could be observed; this might be caused by a decrease of plasma proteins with high frictional ratios compensating the increase of acute phase proteins. Besides, tissue damage and consecutive acute phase reaction in carotid arterial surgery seem to be of relatively minor degree.

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Abbreviations

AP:

Akute Phase

AT3:

Antithrombin III

A1AT:

Alpha-1-Antitrypsin

A2MG:

Alpha-2-Makroglobulin

CER:

Coeruloplasmin

EA:

Erythrozytenaggregation

EF:

Erythrozytenfiltrabilität

FGEN:

Fibrinogen

FN:

Fibronectin

HK:

Hämatokrit

HPT:

Haptoglobin

Ig:

Immunglobulin

LEU:

Leukozyten

PV:

Plasmaviskosität

THR:

Thrombozyten

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Authors and Affiliations

  1. Angiologische Abteilung der 1. Medizinischen Universitätsklinik, Wien

    M. Jung, R. Koppensteiner, E. Minar & H. Ehringer

  2. Universitätsklinik für Chemotherapie, Austria

    W. Graninger

  3. 1. Chirurgische Universitätsklinik, Wien

    G. Kretschmer

Authors
  1. M. Jung
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  2. R. Koppensteiner
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  3. W. Graninger
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  4. E. Minar
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  5. G. Kretschmer
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  6. H. Ehringer
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Jung, M., Koppensteiner, R., Graninger, W. et al. Hämorheologie und Akute Phase Reaktion nach Thrombendarteriektomie der extracraniellen Arteria carotis. Klin Wochenschr 66, 379–384 (1988). https://doi.org/10.1007/BF01737940

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  • DOI: https://doi.org/10.1007/BF01737940

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