Summary
An overview is given on the use of immunoglobulins in clinical neurology. While 5S-immunoglobulins may be employed in addition to virostatics in viral encephalitis, 7S-immunoglobulins can be used in autoimmune diseases like myasthenia gravis, multiple sclerosis, and the Guillain-Barré syndrome. Refractory childhood epilepsies like the Lennox-Gastaut syndrome responded to 7S-immunoglobulins. Hyperimmunoglobulins are to be given in bacterial infections in which toxins are formed and in viral infections caused by cytomegalovirus and tick-borne encephalitis virus. While some open studies report benefit from the use of immunoglobulins in neurological diseases, controlled evidence for their efficacy is still missing.
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Abbreviations
- CSF:
-
Cerebrospinal fluid
- CMV:
-
Cytomegalovirus
- Ig:
-
Immunoglobulin
- CNS:
-
Central nervous system
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Berlit, P. Immunoglobulin therapy in neurologic diseases. Klin Wochenschr 67, 967–970 (1989). https://doi.org/10.1007/BF01716058
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DOI: https://doi.org/10.1007/BF01716058