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Association between serum-soluble CD8 levels and parameters of immune activation in patients with human immunodeficiency virus infection

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Summary

We compared the serum concentrations of soluble CD8 with the immune activation markers neopterin, interferon-γ, tumour necrosis factor-α, soluble CD4, and with CD34+ and CD38+ T-cell counts in patients with human immunodeficiency virus (HIV) infection. The majority of patients had increased concentrations of soluble CD8, interferon-γ and neopterin, and various significant correlations existed between them. Our results support the view that enhanced soluble CD8 levels indicate activated CD8+ T cells in patients with HIV infection.

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Abbreviations

sCD8:

serum-soluble CD8

sCD4:

serum-soluble CD4

IFN-γ:

interferon-γ

TNF:

α=tumour necrosis factor-α

HIV:

human immunodeficiency virus

AIDS:

acquired immunodeficiency virus

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Author notes

  1. D. Fuchs

    Present address: Institut für Medizinische Chemie und Biochemie, Universität Innsbruck, Fritz Pregl Strasse 3, A-6020, Innsbruck, Austria

Authors and Affiliations

  1. Klinische Immunologie und Immunhämatologie, Medizinische Klinik, Universität Graz, Innsbruck, Austria

    G. P. Tilz

  2. AIDS Station, Universitätsklinik für Dermatologie und Venerologie, Universität Innsbruck, Innsbruck, Austria

    R. Zangerle, P. Fritsch & H. Wachter

  3. Institut für Medizinische Chemie und Biochemie, Universität Innsbruck, Innsbruck, Austria

    G. Weiss & D. Fuchs

Authors
  1. G. P. Tilz
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  2. R. Zangerle
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  3. G. Weiss
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  4. P. Fritsch
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  5. H. Wachter
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  6. D. Fuchs
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Tilz, G.P., Zangerle, R., Weiss, G. et al. Association between serum-soluble CD8 levels and parameters of immune activation in patients with human immunodeficiency virus infection. Clin Investig 70, 662–664 (1992). https://doi.org/10.1007/BF00180281

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  • DOI: https://doi.org/10.1007/BF00180281

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