Skip to main content

Advertisement

Log in

Genetic control of Interleukin 12 responsiveness: implications for disease pathogenesis

  • REVIEW
  • Published:
Journal of Molecular Medicine Aims and scope Submit manuscript

Abstract

 We examined the effect of genetic background on Th1/Th2 development. We discuss data demonstrating that genetic background is an important determinant of interleukin-12 (IL-12) responsiveness and the potential implications for disease progression in murine experimental leishmaniasis. Genetic analysis of the differential control of IL-12 responsiveness led to the identification of a controlling locus on the middle portion of murine chromosome 11. This genetic region (or its human counterpart, 5q31) has been associated with increased disease susceptibilities for several atopic, infectious, and autoimmune disorders. We discuss potential roles for genetic control of IL-12 responsiveness in the development of these diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Received: 5 December 1996 / Accepted: 10 March 1997

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gorham, J., Güler, M. & Murphy, K. Genetic control of Interleukin 12 responsiveness: implications for disease pathogenesis. J Mol Med 75, 502–511 (1997). https://doi.org/10.1007/s001090050135

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s001090050135

Navigation