Summary
Intestinal insulin releasing polypeptide (IRP) and Gastric inhibitory polypeptide (GIP) have a similar effect on intravenous glucose tolerance in the rat. Both augment the insulin response to intravenous glucose and increase the rate of glucose disappearance. VIP and motilin have no discernible effect. Plasma insulin dose-response curves to IRP and GIP are similar; both peptides stimulate insulin release in the presence of small blood glucose increments. A direct comparison of the insulin releasing potency of IRP and GIP is not possible as the former is not yet available in pure form.
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Turner, D.S., Marks, V.: Enhancement of glucose-stimulated insulin release by an intestinal polypeptide in rats. Lancet1972 I, 1095–1097
Turner, D.S., Shabaan, A., Etheridge, Lauraine, Marks, V.: The effect of an intestinal polypeptide fraction on insulin release in the ratin vitro andin vivo. Endocrinology93, 1325–1328 (1973)
Said, S.I., Mutt, V.: Isolation from porcine-intestinal wall of a vasoactive octacosapeptide related to secretin and to glucagon. Europ. J. Biochem.28, 199–204 (1972)
Brown, J.C., Mutt, V., Pederson, R.A.: Further purification of a polypeptide demonstrating enterogastrone activity. J. Physiol. (Lond.)209, 57–64 (1970)
Brown, J.C., Cook, M.A., Dryburgh, J.R.: Motilin, a gastric motor activity-stimulating polypeptide; final purification, amino acid composition, and c-terminal residues. Gastroenterology62, 401–404 (1973)
Dupré, J., Ross, S.A., Watson, D., Brown, J.C.: Stimulation of insulin secretion by Gastric Inhibitory Polypeptide in man. J. clin. Endocr.37, 826–828 (1973)
Huggett, A.St.G., Nixon, D.: Use of glucose oxidase, peroxidase, and o-dianisidine in determination of blood and urinary glucose. Lancet1957 II, 368–370
Samols, E., Bilkus, D.A.: A comparison of insulin radioimmunoassays. Proc. Soc. exp. Biol. (N.Y.)115, 79–84 (1964)
Moody, A.J., Markussen, J., Schaich-Fries, A., Sundby, F., Malaisse, W.J., Malaisse-Lagae, F.: The insulin releasing activities of extracts of pork intestine. Diabetologia6, 135–140 (1970)
Turner, D.S.: Unpublished observations
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Turner, D.S., Etheridge, L., Marks, V. et al. Effectiveness of the intestinal polypeptides, IRP, GIP, VIP and motilin on insulin release in the rat. Diabetologia 10, 459–463 (1974). https://doi.org/10.1007/BF01221638
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DOI: https://doi.org/10.1007/BF01221638