Summary
Gastrin and insulin levels following protein ingestion were measured in control subjects, in patients with vagotomy and pyloroplasty and in patients with vagotomy, antrectorny and gastroenterostomy. Peak gastrin levels preceded peak insulin levels, but no relationship between gastrin output and insulin output was found. The insulin response in patients with impaired gastrin release was similar to that seen in patients with normal gastrin release. Insulin levels after oral glucose in patients with malignant Zollinger-Ellison syndrome were similar to those in patients after gastrectomy, in spite of marked differences in gastrin level. These studies do not suggest that gastrin stimulates insulin release.
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Hayes, J.R., Ardill, J. & Buchanan, K.D. Gastrin and insulin release. Diabetologia 11, 89–92 (1975). https://doi.org/10.1007/BF00422824
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DOI: https://doi.org/10.1007/BF00422824