Summary
Dogs with an electromagnetic flowprobe implanted around the superior pancreaticoduodenal artery and with an hydraulic occluder implanted upstream from the flowprobe were examined between the 3rd and the 8th postoperative day. During an oral glucose load, blood flow increased from the beginning of administration to about 25 minutes, but not when blood glucose and plasma IRI exhibit their maxima. The rise of pancreatic blood flow is assumed to be produced by reflexes similar to those stimulating insulin secretion and exocrine pancreatic function during the early phase of an oral glucose load.
Article PDF
Similar content being viewed by others
References
Bennett, A. L., Still, E. U.: A study of the relation of pancreatic duct pressure to the rate of blood flow through the pancreas. Amer. J. Physiol. 106, 454–459 (1933)
Creutzfeldt, W.: Insulin-releasing factors of the gastrointestinal mucosa (incretin). Gastroenterology 67, 748–749 (1974)
Delaney, J. P., Grim, E.: Influence of hormones and drugs on canine pancreatic blood flow. Amer. J. Physiol. 211, 1398–1402 (1966)
Fischer, U., Hommel, H., Ziegler, M., Michael, R.: The mechanism of insulin secretion after oral glucose administration. I. Multiphasic course of insulin mobilization after oral administration of glucose in conscious dogs. Differences to the behaviour after intravenous administration. Diabetologia 8, 104–110 (1972)
Fischer, U., Hommel, H., Schmid, E.: Dynamics of canine pancreatic blood flow and of insulin secretion during an intravenous glucose load. Pflügers Arch. ges. Physiol. 358, 89–100 (1975)
Fischer, U., Hommel, H., Gottschling, D., Heinke, P., Jutzi, E.: Estimation of pancreatic IRI output rate and its relation to glucose tolerance in normal anaesthetized dogs. Diabetologia 11, 291–299 (1975)
Fischer, U., Hommel, H., Nowak, W., Sill, U., Lippert, H.: The mechanism of insulin secretion after oral glucose administration. VII. Exocrine pancreatic function and plasma IRI in dogs with chronic pancreatic fistulas. In preparation
Goodhead, B., Himal, H. S., Zanbjlowicz, J.: Relationship between pancreatic secretion and pancreatic blood flow. Gut 11, 62–68 (1970)
Greenwell, J. R., Scratcherd, T.: The kinetics of pancreatic amylase secretion and its relationship to volume flow and electrical conductance in the anaesthetized cat. J. Physiol. (Lond.) 239, 443–457 (1974)
Hickson, J. C. D.: The secretion of pancreatic juice in response to stimulation of the vagus nerves in the pig. J. Physiol. (Lond.) 206, 275–297 (1970)
Hiebert, J. M., McCormick, J. M., Egdahl, H. E.: Direct measurement of insulin secretory rate: Studies in shocked primates and postoperative patients. Ann. Surg. 176, 296–303 (1971)
Holton, P., Jones, M.: Some observations on changes in the blood content of the cat's pancreas during activity. J. Physiol. (Lond.) 150, 479–488 (1960)
Jacobson, E. D.: The gastrointestinal circulation. Ann. Rev. Physiol. 30, 133–146 (1968)
Kuznetsova, K. E.: Characteristics of blood supply of the pancreas during different phases of its activity. Fiziol. Zh. (Mosk.) 48, 470–478 (1962)
Lefebvre, J. P., Luyckx, A. S.: Régulation de la sécrétion d'insuline par le pancréas de chien in situ. J. Ann. Diab. Hôtel-Dieu 10, 139–155 (1969)
Lefebvre, J. P., Luyckx, A. S.: Effect of ouabain on insulin secretion in the anaesthetized dog. Biochem. Pharmacol. 21, 339–345 (1972)
Lefebvre, J. P., Luyckx, A. S.: Stimulation of insulin secretion after prostaglandin PGE1 in the anaesthetized dog. Biochem. Pharmacol. 22, 1773–1779 (1973)
Lenninger, S.: Effects of acetylcholine and papaverine on the secretion and blood flow from the pancreas of the cat. Acta physiol. scand. 89, 260–268 (1973)
Mandelbaum, J., Morgan, C. R.: Pancreatic blood flow and its relationship to insulin secretion during extracorporeal circulation. Ann. Surg. 170, 753–758 (1969)
Porte, Jr., D., Girardier, L., Seydoux, J., Kanazawa, Y., Posternak, J.: Neural regulation of insulin secretion in the dog. J. clin. Invest. 52, 210–214 (1973)
Reininger, E. J., Sapirstein, L. A.: Effect of digestion on distribution of blood flow in the rat. Science 126, 1176–1176 (1957)
Rushmer, R. F., Franklin, D. L., van Citters, R. L., Smith, O. A.: Changes in peripheral blood flow distribution in healthy dogs. Circulat. Res. 9, 675–687 (1961)
Semb, L. S., Aune, S.: The effect of glucose and insulin on pancreatic blood flow in the anaesthetized pig. Scand. J. clin. Lab. Invest. 27, 105–111 (1971)
Tankel, H. I., Hollander, F.: The relation between pancreatic secretion and local blood flow. A review. Gastroenterology 32, 633–641 (1957)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fischer, U., Hommel, H. & Salzsieder, E. Pancreatic blood flow in conscious dogs after oral administration of glucose. Diabetologia 12, 133–136 (1976). https://doi.org/10.1007/BF00428978
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00428978