Summary
Glucagon (1 mg) and glucose (60 ml of 50% solution) were infused over 60 min to three normal and one obese subjects and two insulinoma patients. Plasma C-peptide immunoreactivity (CPR) and immunoreactive insulin (IRI) increased during the infusion. Half time of CPR after cessation of the infusion was 20.1±4.0 min, and that of IRI 9.8±1.3 min, respectively. This difference partly explains the higher molar concentration in plasma of CPR than IRI.
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Kuzuya, T., Matsuda, A. Disappearance rate of endogenous human C-peptide from blood. Diabetologia 12, 519–521 (1976). https://doi.org/10.1007/BF01219517
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DOI: https://doi.org/10.1007/BF01219517