Summary
The kidney growth seen after the induction of experimental diabetes in rats has been compared to the compensatory renal growth after one-sided nephrectomy. After five days the kidney weight had increased from 650 ± 15 mg in a group of controls to 778 ± 21 mg in diabetic rats, and 764 ±17 mg in unilaterally nephrectomised rats. The increased weight was in both groups reflected in an increased DNA content and increased RNA/DNA and protein/DNA ratios. In a group of rats made diabetic and nephrectomised at the same time, kidney weight increased to 953 ± 22 mg after five days. When rats were unilaterally nephrectomised after 20 days of untreated diabetes, compensatory growth was much more pronounced than in non-diabetic rats, kidney weight rising from 780 ± 21 to 1144 ± 39 mg in five days. Similarly, in rats with established compensatory renal hypertrophy, diabetes induced a very rapid growth of the remaining kidney (1226 ± 46 mg after five days).
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Ross, J., Goldman, A.K.: Effect of streptozotocin-induced diabetes on kidney weight and compensatory hypertrophy in the rat. Endocrinology88, 1079–1082 (1971)
Seyer-Hansen, K.: Renal hypertrophy in streptozotocin-diabetic rats. Clin. Sci. Mol. Med.51, 551–555 (1976)
Seyer-Hansen, K.: Renal hypertrophy in experimental diabetes: relation to severity of diabetes. Diabetologia13, 141–143 (1977)
Munro, A.N., Fleck, A.: The determination of nucleic acids. Methods Biochem. Anal.14, 113–176 (1966)
Burton, K.: A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem. J.62, 315–323 (1956)
Lowry, A.H., Rosebrough, A.J., Farr, A.L., Randall, A.J.: Protein measurement with the Folin phenol reagent. J. Biol. Chem.193, 265–275 (1951)
Kurnick, A.B., Lindsay, A.A.: Nucleic acids in compensatory renal hypertrophy. Lab. Invest.18, 700–708 (1968)
Preuss, A.G., Goldin, H.: A renotropic system in rats. J. Clin. Invest.57, 94–101 (1976)
Mauer, A.M., Steffes, A.W., Brown, A.M.: Effects of reduction in renal mass on the glomerular lesions of diabetes mellitus in rats (Abstract). Diabetes25 (suppl. 1), 349 (1976)
Mauer, A.M., Barbosa, J., Vernier, A.L., Kjellstrand, A.M., Buselmeier, A.J., Simmons, A.L., Najarian, A.S., Goetz, A.D.: Development of diabetic vascular lesions in normal kidneys transplanted into patients with diabetes mellitus. N. Engl. J. Med.295, 916–920 (1978)
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Seyer-Hansen, K. Renal hypertrophy in experimental diabetes: A comparison to compensatory hypertrophy. Diabetologia 14, 325–328 (1978). https://doi.org/10.1007/BF01223024
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DOI: https://doi.org/10.1007/BF01223024